摘要
目的探讨老年人营养代谢状态(体质量指数)与髋部骨密度(bone mineral density,BMD)的关系。方法收集2019年1月至2021年6月于福建医科大学附属泉州第一医院就诊的老年女性骨质疏松症患者430例。记录患者的年龄、身高、体重、尿酸、肌酐、肾小球滤过率(GFR)、髋部BMD、甲状旁腺素(PTH)、N端骨钙素(N-Osrteoc)、I型原胶原N端前肽(PINP)、25羟基维生素D3(25-OH-D3)。各指标相关性检验采用Pearson相关性检验。结果不同年龄组的BMD、GFR之间有统计学差异,并呈负相关,不同年龄组的体质量指数(body mass index,BMI)、尿酸氮、肌酐、尿酸、PTH、N-Osrteoc、PINP比较差异无统计学意义,与25-OH-D3比较差异有统计学意义并呈正相关。不同尿酸组内骨代谢标志物比较差异无显著性,各组间BMI、BMD、尿酸氮、肌酐比较差异有显著性并呈正相关,GRF比较差异有显著性并呈负相关;不同骨密度组之间BMI、尿酸氮、肌酐、尿酸、GRF比较差异有显著性,并与BMI、尿酸氮、肌酐、尿酸呈正相关,与GRF呈负相关,各组骨代谢标志物比较差异无显著性。结论BMI会引起体内尿酸的改变,保持一定量的BMI及尿酸对于老年女性骨密度的维持有积极作用,这种作用与体内激素变化引起的骨代谢变化不相关。
Objective To study the relationship between nutritional metabolism(body mass index)and hip bone mineral jbdensity(BMD)in the elderly.Methods 430 elderly female patients with osteoporosis from January 2019 to June 2021 were collected.The age,height,weight,uric acid,creatinine,glomerular filtration rate(GFR),hip BMD,parathyroid hormone(PTH),N-terminal Osteocalcin(n-osrteoc),N-terminal procollagen I(PINP),25 hydroxyvitamin D 3(25-OH-D3)were recorded.Pearson correlation test was used for the correlation test of each index.Results There were significant differences and negative correlation between BMD and GFR in different age groups.There was no significant difference in BMI,uric acid nitrogen,creatinine,uric acid,PTH,n-osrteoc and PINP in different age groups,but there was significant and positive correlation in 25-OH-D3.There was no significant difference in bone metabolism markers in different uric acid groups.There was significant and positive correlation in BMI,BMD,uric acid nitrogen and creatinine,and significant and negative correlation in GRF;There were significant differences in BMI,uric acid nitrogen,creatinine,uric acid and GRF in different BMD groups,and there was a positive correlation with BMI,uric acid nitrogen,creatinine and uric acid,and a negative correlation with GRF.There was no significant difference in bone metabolism markers in BMD groups.Conclusion Changes of BMI lead to the change of uric acid in vivo.Maintaining a certain BMI and uric acid has a positive effect on the maintenance of bone mineral density in elderly women.This effect is not related to the change of bone metabolism caused by hormone changes in vivo.
作者
陈巧凤
谢俊杰
施建辉
林勇军
CHEN Qiaofeng;XIE Junjie;SHI Jianhui;LIN Yongjun(Department of Orthopedics,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000;Department of General Practice,Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2022年第12期1782-1786,共5页
Chinese Journal of Osteoporosis
基金
福建省自然科学基金(2021J011406)。
关键词
骨质疏松症
体质量指数
尿酸
肾小球滤过率
肾功能
osteoporosis
body mass index
uric acid
glomerular filtration rate
renal function
