摘要
目的探索骨代谢指标在骨病、肾病和心血管疾病中的变化规律及与常规生化指标间的相关性。方法回顾性分析临床确诊为骨骼疾病(163例)、肾脏疾病(204例)和心脑血管病(211例)患者和正常人组(75例)的:骨钙素(Osteocalcina,OCN)、甲状旁腺激素(Parathormon,PTH)、Ⅰ型胶原羧基端前肽(β-Crosslaps,β-CTx)骨代谢指标及钙(Calcium,Ca)、磷(Phosphorus,P)、尿素(Urea,UN)、尿酸(Uric Acid,UA)、肌酐(Creatinine,Cr)、碱性磷酸酶(Alkaline Phosphatase,ALP)和半胱氨酸(Homocysteic acid,HCY)相关生化指标。结果β-CTx在年龄≤50岁与年龄>50岁女性的三种疾病组和正常对照组有统计学差异。PTH在四组中差异显著(P<0.05)。经过Pearson相关性分析,β-CTx与ALP相关系数为0.345(P<0.05);OCN与Cr r=0.361(P<0.05),与ALP r=0.437(P<0.05),与PTH r=0.600(P<0.05);PTH与ALP r=0.509(P<0.05)。结论骨代谢指标检测对肾脏疾病、心脑血管疾病等有一定辅助诊断价值。
Objective To study the changing rule of bone metabolic markers in patients with bone,kidney and cardiovascular diseases and its correlation with routine biochemical parameters.Methods Three bone metabolic markers including osteocalcin（OCN）,β-crosslaps（β-CTx）,parathyroid hormone（PTH）,and 6 routine biochemical parameters including calcium（Ca）,phosphorus（P）,urea（UN）,uric acid（UA）,creatinine（Cr）,alkaline phosphatase（ALP）,and homocysteic acid（HCY） were retrospectively analyzed in 163 patients with bone disease,204 patients with kidney disease,211 patients with cardiovascular disease,and 75 healthy volunteers.Results The β-CTx and PTH level was higher in female patients with bone,kidney and cardiovascular diseases at the age≤50 or 50 years than in controls（P0.05）.Pearson correlation analysis showed that the β-CTx OCN,and PTH were correlated with ALP,OCN,Cr,and PTH,with a correlation coefficient of 0.361,0.437,0.600,and 0.509,respectively（P0.05）.Conclusion Bone metabolic markers can be used not only in diagnosis of bone disease,but also in evaluation of kidney and cardiovascular diseases and cancer.
出处
《军医进修学院学报》
CAS
2011年第1期25-27,共3页
Academic Journal of Pla Postgraduate Medical School
基金
国家科技支撑计划项目(2009BAI86B05)~~
