摘要
目的探讨糖尿病肾病(diabetic kidney disease,DKD)患者相关肠道菌群分布变化与炎症指标的相关性。方法选取2018年11月至2019年7月湖州市第三人民医院收治的T2DM患者46例,以是否并发慢性肾脏疾病为依据,分为T2DM组(25例)与DKD组(21例)。另于同期选取健康体检者25例设为对照组。比较三组肠道菌群分布及变化、炎症指标[肿瘤坏死因子α(tumor necrosis factor alpha,TNF-α)、白细胞介素6(interleukin 6,IL-6)、白细胞介素8(interleukin 8,IL-8)、超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)]水平,并分析肠道细菌水平与炎症指标的相关性。结果TNF-α、IL-6、hs-CRP水平比较:DKD组>T2DM组>对照组,差异有统计学意义[(29.46±9.71)vs(20.94±6.55)vs(8.55±2.21)ng/L,(30.64±10.17)vs(21.31±6.38)vs(8.91±2.25)ng/L,(418.15±12.44)vs(325.23±11.62)vs(279.41±9.46)μmol/L,P<0.05];DKD组、T2DM组的IL-8水平明显高于对照组[(6.16±1.28)vs(5.54±0.84)(P<0.05)]。三组乳酸杆菌数、酵母菌数比较,差异无统计学意义(P>0.05);三组双歧杆菌数、真杆菌数比较:DKD组<T2DM组<对照组[(5.73±0.35)vs(7.38±0.67)vs(9.88±2.73),(7.95±0.74)vs(9.04±0.86)vs(10.06±0.66),P<0.05];三组大肠杆菌数比较:DKD组>T2DM组>对照组,差异有统计学意义[(11.36±0.43)vs(10.51±0.34)vs(9.89±0.52),P<0.05]。Pearson分析显示,双歧杆菌数与TNF-α、IL-6、IL-8、hs-CRP均呈负相关(P<0.05);真杆菌数与TNF-α、IL-6、hs-CRP呈负相关(P<0.05);大肠杆菌数与TNF-α、IL-6、IL-8、hs-CRP均呈正相关(P<0.05)。结论DKD患者肠道细菌分布和数量及炎症因子水平均有异常表现,且二者密切相关,关注T2DM患者肠道菌群及炎性因子水平或可为慢性肾病防治提供新思路。
Objective To investigate the correlation between the distribution and changes of intestinal flora associated with diabetic kidney disease(DKD)and inflammation indicators.Methods Based on whether complicated with chronic kidney disease,patients were divided into T2DM group(25 cases)and DKD group(21 cases).In the same period,25 patients undergoing physical examination were selected as the control group.The three groups were compared in terms of intestinal flora distribution and changes,and levels of inflammation indicators[Tumor necrosis factor alpha(TNF-α),interleukin 6(Interleukin 6,IL-6),interleukin 8(Interleukin 8,IL-8),high sensitive C-reactive protein(hs-CRP)].The correlation between intestinal bacterial levels and inflammation indicators was analyzed.Results In terms of TNF-α,IL-6,hs-CRP levels,the results were as the following:DKD group>T2DM group>control group,and the difference was statistically significant(P<0.05);IL-8 levels in T2DM group and DKD group were significantly higher than those in the control group(P<0.05).There was no significant difference in the number of lactobacilli or yeasts among the three groups(P>0.05).In terms of the number of bifidobacteria and true bacteria,the results were as the following:DKD group<T2DM group<control group,and the comparison of the three groups E.coli number:DKD group>T2DM group>control group,and the difference was statistically significant(P<0.05).Pearson analysis showed that the number of bifidobacteria was negatively correlated with TNF-α,IL-6,IL-8,and hs-CRP(P<0.05);the number of true bacteria was correlated with TNF-α,IL-6,hs-CRP Negative correlation(P<0.05);the number E.coli was positively correlated with TNF-α,IL-6,IL-8,and hs-CRP(P<0.05).Conclusions The distribution and number of intestinal bacteria and the levels of inflammatory factors in DKD patients are abnormal,and the two are closely related.Paying attention to the intestinal flora and levels of inflammatory factors in T2DM patients may provide new ideas for e prevention and treatment of chron
作者
李雷
张帆
方飞
沈知行
赵进和
Li Lei;Zhang Fan;Fang Fei;Shen Zhixing;Zhao Jinhe
出处
《中华内分泌外科杂志》
CAS
2020年第6期507-510,共4页
Chinese Journal of Endocrine Surgery
基金
湖州市科学技术局项目(2018GYB39)。
关键词
2型糖尿病
糖尿病肾病
肠道菌群
炎症指标
Type 2 diabetes
Diabetic nephropathy
Intestinal flora
Inflammation index
