摘要
糖尿病肾病(diabetic nephropathy,DN)是糖尿病最严重的血管并发症,是导致终末期肾脏疾病的主要原因之一,目前认为其发病是糖脂代谢紊乱和血流动力学变化,细胞因子、炎性反应、氧化应激、遗传易感性等多种因素共同作用的结果。肠道菌群失调可通过影响炎性反应、肾素-血管紧张素系统等多种途径参与DN的发生、发展。本文就肠道菌群的结构、组成,肠道菌群失调与DN的关系,调整肠道菌群失调对DN潜在治疗作用的研究进展作一综述。
Diabetic nephropathy is the most serious vascular complication of diabetes and is one of the leading causes of end-stage renal disease.Its pathogenesis is currently believed to be the result of various factors such as glycolipid metabolism and hemodynamic changes as well as cytokines,inflammatory responses,oxidative stress,and genetic susceptibility.Gut microbiota imbalance is involved in the occurrence and development of diabetic nephropathy by affecting inflammation responses,immunity,and renin-angiotensin system.This paper reviews the research progress of the structure and composition of gut microbiota,the relationship of gut microbiota imbalance with diabetic nephropathy,and potential role of correcting gut microbiota imbalance in diabetic nephropathy.
作者
姚碧晴
陈铖
YAO Biqing;CHEN Cheng(Department of Nephrology,Renmiri Hospital of Wuhan University,Wuhan 430060,China)
出处
《中华实用诊断与治疗杂志》
2020年第1期102-105,共4页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家科技支撑计划资助项目(2017HX0002)
关键词
糖尿病肾病
肠道菌群
菌群失调
diabetic nephropathy
gut microbiota
microbiota imbalance
