摘要
荧光技术具有操作简便、分辨率高且可实现实时成像等特点,已被广泛应用于生物医学检测和成像领域,其中,近红外二区荧光染料(NIR-Ⅱ,1000～1700 nm)由于其发射波长较长,光散射和组织自发荧光干扰较少,在生物组织成像中具有更高的时空分辨率和更深的成像深度。本文主要介绍了基于近红外二区荧光探针的设计原理及其在生物成像领域的研究现状,并对其发展作了进一步展望。
Due to simple operation, high resolution and real-time imaging,fluorescence technology has been widely used in detection and bioimaging. The second near-infrared window dyes(NIR-Ⅱ, 1000~1700 nm) have longer emission wavelength, less interference with light scattering and tissue autofluorescence, resulting in higher temporal and spatial resolution and deeper imaging depth in tissue imaging. In this review, we mainly introduce the designed mechanism and research progress in bioimaging based on NIR-Ⅱ dyes, and further give an outlook in the following studies.
作者
苏哲
秦文璟
白磊
孙鹏飞
余昌敏
范曲立
李林
SU Zhe;QIN Wenjing;BAI Lei;SUN Pengfei;YU Changmin;FAN Quli;LI Lin(Key Laboratory of Flexible Electronics(KLOFE)& Institute of Advanced Materials(IAM),Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM),Nanjing Tech University(NanjingTech),Nanjing 211816,China;Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors,Institute of Advanced Materials(IAM),Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM),Nanjing University of Posts & Telecommunications,Nanjing 210023,China)
出处
《应用化学》
CAS
CSCD
北大核心
2019年第2期123-136,共14页
Chinese Journal of Applied Chemistry
基金
国家自然科学(81672508
61505076
21708034)
江苏省杰出青年基金(BK20170041)资助~~
关键词
近红外二区
荧光成像
纳米材料
共轭聚合物
second
near-infrared
fluorescenceimaging
nanomaterials
conjugated
polymer
