摘要
与可见光和近红外一区光相比,生物组织对近红外二区光具有更低的散射和自体荧光,因此,近红外二区荧光成像技术可以实现高灵敏度、高分辨率和高信噪比的成像,在肿瘤诊断、小分子体内检测、生物传感和免疫分析等领域展示出了广泛的应用前景。在众多的近红外二区荧光纳米材料中,稀土发光纳米材料因具有化学稳定性和光稳定性好、发射带窄、发光颜色和寿命可调等优点受到研究人员的关注。基于此,本文以稀土发光纳米材料的发光机理和设计合成为出发点,系统地综述了这类纳米材料在近红外二区荧光成像方面的最新研究进展,并对其亟需解决的问题及未来的发展趋势进行了展望。
Compared to the visible range(Vis,400-700 nm)and first near-infrared window(NIR-Ⅰ,700-1000 nm),fluorescence-based imaging in the second near-infrared window(NIR-Ⅱ,1000-1700 nm)possesses the merits of high sensitivity,spatiotemporal resolution and signal to noise ratio(SNR)with increasing tissue penetration depths benefiting from the optical scattering and auto-fluorescence in the biological tissue,leading to widespread application in the fields of tumor diagnosis,biosensing,in vivo molecular detection and immunoassay.Among of several NIR-Ⅱfluorescence probes,lanthanide-doped luminescence nanomaterials have attracted more attention in development of NIR-Ⅱfluorescence imaging,owing to the advantages of high photostability and chemostability,narrow emission band widths,tunable emission wavelength and lifetime.Therefore this work takes the mechanisms and constitutions of lanthanide-doped luminescence nanomaterials as starting points and systematically summarizes the recent progress in the biomedical imaging and biosensing applications of lanthanide-doped luminescence nanomaterials.The problem to be resolved and its future development are discussed.
作者
张松涛
王樱蕙
张洪杰
ZHANG Song-tao;WANG Ying-hui;ZHANG Hong-jie(State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;University of Chinese Academy of Sciences, Beijing 100049, China;Department of Chemistry, Tsinghua University, Beijing 100084, China)
出处
《发光学报》
EI
CAS
CSCD
北大核心
2020年第12期1460-1478,共19页
Chinese Journal of Luminescence
基金
国家自然科学基金(51502284,21834007,21521092,21590794,21673220)
中国科学院青年创新促进会(2019232)资助项目。
关键词
稀土发光纳米材料
荧光探针
近红外二区
荧光成像
lanthanide-doped luminescence nanomaterials
fluorescence probe
NIR-Ⅱ
fluorescence imaging
