摘要
宫颈癌是最常见的妇科恶性肿瘤之一,早期、有效的诊断与治疗对提高患者生存率及生活质量具有重要意义。荧光成像已被广泛应用于癌症的早期检测,但由于光在深层组织内传播时,受穿透深度和散射的影响,不利于实现深层组织高清成像。近红外二区(near-infrared-Ⅱ,NIR-Ⅱ;900~1700nm)成像技术与近红外一区(near-infrared-Ⅰ,NIR-Ⅰ;760~900 nm)成像技术相比,具备更高的信噪比和对比度、更低的自发荧光和更高的空间分辨率,是当前光学、生物医学等多学科的研究热点,非常适合宫颈癌的高质量荧光成像。高质量的荧光成像需要借助良好的荧光探针来精确定位肿瘤组织及其边界并监测治疗过程。目前已开发了一系列基于有机和无机材料的NIR-Ⅱ荧光探针。本文概述了几种典型的NIR-Ⅱ荧光探针及其辅助的NIR-Ⅱ荧光成像技术在宫颈癌成像及治疗方面的应用。
Cervical cancer is one of the most common gynecological malignant tumors.Early diagnosis and treatment are of great significance to improve the survival rate and quality of life of patients.Fluorescence imaging has been widely used in the early detection of cancer.However,due to the scattering of light when propagates in deep tissues,the resolution of the imaging quality is limited.Compared with the light in the first near⁃infrared spectral window(NIR-Ⅰ,760-900 nm),the light in the second near⁃infrared(NIR-Ⅱ,900-1700 nm)spectral window greatly overcomes the problem of photon scattering,which endow the NIR-Ⅱimaging deeper tissue penetration,higher signal⁃to⁃noise ratio and spatial resolution.Thus NIR-Ⅱfluorescence imaging is currently a hot topic of multi⁃disciplinary research in optics,biomedicine⁃related fields,as well as ideal for imaging of cervical cancer.Fluorescence probes are of great importance for the high⁃quality fluorescence imaging which can accurately locate the tumor site with boundaries clearly and monitor the treatment process.This paper summarizes the research progress of several typical kinds of NIR-Ⅱfluorescence probes,and the probes assisted NIR-Ⅱfluorescence imaging and therapy of cervical cancer.
作者
古丽妮尕尔·阿里木
闫婷
朱丽君
樊慧敏
努尔尼沙·阿力甫
张学良
ALIMU Gulinigaer;YAN Ting;ZHU Lijun;FAN Huimin;ALIFU Nuernisha;ZHANG Xueliang(Institute of Public Health,Xinjiang Medical University,Urumqi 830011;School of Medical Engineering and Technology,Xinjiang Medical University,Urumqi 830011)
出处
《北京生物医学工程》
2023年第1期100-105,共6页
Beijing Biomedical Engineering
基金
国家自然科学基金重点项目(62035011)
国家自然科学基金地区项目(82060326)
省部共建中亚高发病成因与防治国家重点实验室开放课题重点项目(SKLHIDCA-2019-3)
新疆维吾尔自治区自然科学基金项目(2020D01C151)资助。
关键词
近红外二区
荧光成像技术
宫颈癌
荧光探针
成像与治疗
near⁃infrared-Ⅱ
fluorescence imaging technology
cervical cancer
fluorescence probe
imaging and therapy
