摘要
肿瘤早期检测是精准并高效诊疗癌症的关键因素。荧光成像技术凭借其高灵敏度、高时空分辨率、无电离辐射和无创实时成像等优点,在生物医学领域,尤其在肿瘤检测方面展现出了广泛的应用前景。近红外光穿过生物组织时,受到的吸收和散射较少,因此在生物成像方面体现了高信噪比和强组织穿透能力。在众多荧光探针中,近红外发光的量子点探针因其量子产率高、抗光漂白性强、发射光可调和稳定性良好等特点在荧光成像方面显示出突出的优势。本文基于量子点探针的近红外荧光成像技术在肿瘤显影中的应用,介绍了量子点优异的光学性能,并重点讨论了硫化铅(PbS)和硫化银(Ag_(2)S)近红外发光量子点探针在肿瘤成像方面的研究进展,并对近红外发光量子点探针的应用前景进行了展望。
Early tumor detection is a key factor for precise diagnosis and effective treatment of cancer.With the advantages of high sensitivity,excellent temporal and spatial resolutions,non-ionizing radiation,non-invasive and real-time imaging,fluorescence imaging technology has showed broad application prospects in biomedicine,especially in tumor detection.When near-infrared light penetrates biological tissues,there were less light absorption and scattering.Therefore,near-infrared light has high signal-to-noise ratio and deep tissue penetration in bioimaging.Among various fluorescent probes,nearinfrared fluorescent quantum dot probes show outstanding properties in fluorescence imaging,such as high quantum yield,strong resistance to photobleaching,adjustable emission light and good stability.Herein the application of quantum dot probes assisted near-infrared fluorescence imaging technology in tumor imaging was reviewed;and the excellent optical properties of quantum dots were introduced;and the advances of research on lead sulfide(PbS)and silver sulfide(Ag_(2)S)nearinfrared fluorescence quantum dot probes in tumor imaging were mainly summarized;and finally the application prospects of near-infrared fluorescent quantum dot probes is discussed.
作者
樊慧敏
朱丽君
马燕
努尔尼沙·阿力甫
FAN Huimin;ZHU Lijun;MAYan;ALIFU Nuernisha(State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia/School of Medical Engineering and Technology,Xinjiang Medical University,Urumqi 830011,China)
出处
《中国医学物理学杂志》
CSCD
2021年第6期688-691,共4页
Chinese Journal of Medical Physics
基金
国家自然科学基金(82060326)
省部共建中亚高发病成因与防治国家重点实验室开放课题重点项目(SKL-HIDCA-2019-3)
新疆维吾尔自治区自然科学基金(2020D01C151)
自治区高校科研计划自然科学青年项目(XJEDU2018Y026)。
关键词
近红外
量子点探针
肿瘤显影
荧光成像
综述
near-infrared
quantum dot probe
tumor imaging
fluorescence imaging
review
