摘要
目的探究采用滋阴活血方联合羟苯磺酸钙胶囊治疗单纯性糖尿病视网膜病变(DR)患者的临床疗效。方法选择2012年10月至2015年10月来该院治疗的单纯性DR患者248例(406只眼),随机分为对照组(124例,208只眼)和研究组(124例,198只眼)。对照组给予羟苯磺酸钙胶囊治疗,研究组在对照组基础上,加用自拟滋阴活血方治疗,观察两组患者视力、患者眼底治疗前后变化情况,以及评价治疗后患者症状改善情况。结果治疗后研究组视力总有效率为95.2%,明显高于对照组的85.4%,差异有统计学意义(P<0.05)。治疗后研究组眼底总有效率为90.4%,明显高于对照组的79.3%,差异有统计学意义(P<0.05)。治疗后研究组针对证候的总有效率为96.7%,明显高于对照组的79.8%,差异有统计学意义(P<0.05)。治疗前两组患者的血清血管内皮生长因子(VEGF)和胰岛素一号增长因子(IGF-1)水平比较,差异无统计学意义(P>0.05)。治疗后两组血清中VEGF和IGF-1均有所降低,与治疗前比较,差异均有统计学意义(P<0.05)。治疗后研究组VEGF和IGF-1水平明显低于对照组,差异均有统计学意义(P<0.05)。结论滋阴活血方联合羟苯磺酸钙胶囊治疗对单纯性DR患者临床效果明显,能有效改善患者视力,降低患者VEGF和IGF-1水平,值得临床推广。
Objective To explore the effect of Ziyinhuoxuefang combined with Calcium Dobesilate Capsules on the treatment of simple diabetic retinopathy patients.Methods A total of 248patients（406eyes）with simple diabetic retinopathy from October2012 to October 2015 in Traditional Chinese Medicine Hospital of Xi′an were randomly divided into control group（124cases,208eyes）and treatment group（124cases,198eyes）.Patients in the control group were given Ziyinhuoxuefang,while patients in the treatment group were given Ziyinhuoxuefang combined with Calcium Dobesilate Capsules.Vision,the status of fundus and symptoms before and after treatment were observed in the two groups.Results The total effective treatment rate of vision in the treatment group was 95.2%,which was significant higher than 85.4%in the control group（P〈0.05）.The total effective treatment rate of fundus in the treatment group was 90.4%,which was significant higher than 79.3%in the control group（P〈0.05）.The total effective treatment rate of symptoms in the treatment group was 96.7%,which was significant higher than 79.8%in the control group（P〈0.05）.Serum vascular endothelial growth factor（VEGF）and insulin growth factor（IGF-1）before treatment in the two groups had no significant differences（P〉0.05）.After treatment,VEGF and IGF-1in the two groups were all decreased significantly（P〈0.05）.VEGF and IGF-1in the treatment group after treatment were significant lower than those of the control group（P〈0.05）.Conclusion Ziyinhuoxuefang combined with Calcium Dobesilate Capsules have significant effect on simple diabetic retinopathy patients,could improve vision,reduce VEGF and IGF-1effectively.
作者
金兰
JIN Lan(Department of Ophthalmology, Xi＇an Hospital of Traditional Chinese Medicine, Xi＇an , Shaanxi 710021, China)
出处
《检验医学与临床》
CAS
2016年第19期2778-2780,共3页
Laboratory Medicine and Clinic
关键词
滋阴活血
羟苯磺酸钙胶囊
单纯性糖尿病视网膜病变
血管内皮细胞生长因子
胰岛素样生长因子
Ziyinhuoxuefang
Calcium Dobesilate Capsules
simple diabetic retinopathy
background diabetic retinopathy
serum vascular endothelial growth factor
insulin growth factor
