摘要
目的探讨奥扎格雷钠对糖尿病肾病患者尿白蛋白排泄量的影响。方法 160例糖尿病肾病患者分为2组,每组80例。对照组给予饮食控制、口服降糖药物或应用胰岛素等常规治疗,观察组在常规治疗的基础上给予奥扎格雷钠80 mg,加生理盐水250 mL,静脉滴注2 h以上,每日1次,15 d为1个疗程。疗程结束后检测2组患者尿白蛋白定量。结果治疗前2组尿白蛋白排泄量比较差别无统计学意义(P>0.05);2组治疗后尿白蛋白排泄量均明显低于治疗前,差别有统计学意义(P<0.01);治疗后观察组尿白蛋白排泄量明显低于对照组,差别有统计学意义(P<0.01)。2组治疗期间均未出现明显不良反应。结论奥扎格雷钠能显著降低糖尿病肾病患者的尿白蛋白排泄量。
Objective To explore the effect of sodium ozagrel on urinary albumin excretion in patients with diabetic nephropathy.Methods One hundred and sixty patients with diabetic nephropathy were divided into control group and observation group,80 cases in each group.The patients in control group were given alimentary control,oral hypoglycemic drugs or insulin and other conventional treatment,based on these,the patients in observation group were treated with 80 mg sodium ozagrel plus into 250 mL normal saline by intravenous infusion for more than 2 hours,once a day for 15 days.The contents of urinary albumin were determined in two groups after treatment.Results There was no significant difference in urinary albumin excretion between two groups before treatment（P0.05）;Urinary albumin excretion was obviously lower after treatment than that before treatment in observation group and control group（P0.01）;The urinary albumin excretion was obviously lower in observation group than that in control group after treatment（P0.01）.Significant adverse reactions were not found in two groups during treatment.Conclusion Ozagrel sodium can significantly reduce the urinary albumin excretion in patients with diabetic nephropathy.
出处
《新乡医学院学报》
CAS
2010年第4期382-383,共2页
Journal of Xinxiang Medical University
关键词
糖尿病肾病
尿白蛋白
奥扎格雷钠
diabetic nephropathy
urinary albumin
sodium ozagrel
