摘要
目的探究来曲唑联合尿促性素(HMG)治疗对多囊卵巢综合征(PCOS)患者性激素水平及排卵效果的影响。方法选取2020年8月—2021年8月河南省某医院收治的76例PCOS患者作为研究对象。采用随机数字表法将患者分成对照组与研究组,每组38例。对照组患者采用HMG治疗,研究组患者在对照组治疗基础上加用来曲唑治疗。比较2组患者排卵率、单卵泡排卵率;比较2组患者治疗前后性激素水平,包括卵泡刺激素(FSH)、总睾酮(T)、雌二醇(E_(2))、黄体生成素(LH);比较2组患者治疗前后子宫内膜厚度、排卵数、成熟卵泡数;比较2组患者妊娠结局及用药不良反应发生情况。结果研究组患者排卵率、单卵泡排卵率均高于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者FSH、LH、E_(2)、T水平比较,差异无统计学意义(P>0.05)。治疗后,2组患者FSH、LH、E_(2)水平高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。治疗后,2组患者T水平低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者子宫内膜厚度、排卵数、成熟卵泡数比较,差异无统计学意义(P>0.05)。治疗后,2组患者子宫内膜厚度大于治疗前,研究组大于对照组,差异均有统计学意义(P<0.05)。治疗后,2组患者排卵数、成熟卵泡数多于治疗前,且研究组多于对照组,差异均有统计学意义(P<0.05)。研究组患者妊娠率高于对照组,差异有统计学意义(P<0.05)。2组患者用药不良反应发生率比较,差异无统计学意义(P>0.05)。结论来曲唑联合HMG治疗PCOS的临床效果显著,改善患者性激素水平,促进患者排卵及卵泡成熟,安全性高,具有很高治疗价值,建议临床推广应用。
Objective To investigate the effects of letrozole combined with human menopausal gonadotropin(HMG)on sex hormone levels and ovulation in patients with polycystic ovary syndrome(PCOS).Methods A total of 76 patients with PCOS admitted to a hospital in Henan Province from August 2020 to August 2021 were selected as subjects,who were assigned to a control group and an experimental group using the random number table method,with 38 cases in each group.Patients in the control group received HMG therapy,and patients in the experimental group received letrozole in combination with HMG therapy.The ovulation rate and single follicle ovulation rate were compared between the two groups;the hormone levels,including follicle-stimulating hormone(FSH),total testosterone(T),estradiol(E_(2))and luteinizing hormone(LH),were compared before and after the treatment.The endometrial thickness,ovulation number and mature follicle number were compared before and after the treatment;the pregnancy outcomes and the incidence of adverse drug reactions were compared between the two groups.Results The ovulation rate and single follicle ovulation rate in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).No statistically significant difference in the levels of FSH,LH,E_(2)and T was observed between the 2 groups of patients before the treatment(P>0.05).The levels of FSH,LH and E_(2)in the 2 groups after the treatment were higher than those before the treatment,with the experimental group higher than the control group,and the differences were statistically significant(P<0.05).The T levels of patients in the 2 groups after the treatment were lower than those before the treatment,with the experimental group was lower than the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the endometrial thickness,ovulation number and number of mature follicles before the treatment between the 2 groups(P>0.05).The endome
作者
高明娟
谢梦霞
孟肖燕
Gao Mingjuan;Xie Mengxia;Meng Xiaoyan(Zhoukou Yongshan Hospital,Zhoukou Henan 461300,China)
出处
《保健医学研究与实践》
2022年第6期14-17,34,共5页
Health Medicine Research and Practice
关键词
多囊卵巢综合征
来曲唑
尿促性素
排卵
性激素
妊娠结局
Polycystic ovary syndrome
Letrozole
Human menopausal gonadotropin
Ovulation
Sex hormone
Pregnancy outcome
