摘要
目的:探讨来曲唑联合曲普瑞林治疗多囊卵巢综合征(PCOS)合并排卵障碍,对患者临床妊娠率及血清性激素结合球蛋白(SHBG)、胰岛素样生长因子1(IGF-1)水平的影响。方法:选取2019年1月-2021年3月本院收治的PCOS合并排卵障碍患者116例,随机数字表法分两组各58例,对照组采用来曲唑治疗,联合组接受来曲唑联合曲普瑞林治疗,对比两组诱发排卵日排卵效果、妊娠结局、性激素及SHBG、IGF-1水平。结果:治疗后联合组诱发排卵日子宫内膜厚度、成熟卵泡数高于对照组,排卵率(96.6%)、妊娠率(37.9%)、卵巢囊肿(1.7%)、卵泡过度刺激综合征发生率(0)均低于对照组(72.4%、20.7%、13.8%、8.6%),E_(2)水平均高于对照组,LH、FSH低于对照组,SHBG(159.46±65.74 mmol/L)高于对照组(139.54±62.46 mmol/L),IGF-1(270.78±41.39μg/L)低于对照组(321.32±62.95μg/L)(P<0.05)。结论:来曲唑联合曲普瑞林治疗有助于改善患者性激素、SHBG、IGF-1水平,提高临床妊娠率。
Objective: To explore effects of letrozole combined with triprireline for treating patients with polycystic ovarian syndrome(PCOS) complicated with ovulation disorders on their clinical pregnancy rate and serum sex hormone binding globulin(SHBG) and insulin-like growth factor-1(IGF-1) levels. Methods: A total of 116 patients with PCOS complicated with ovulation disorder were selected and were divided into control group and observation group(58 patients in each group) according to random number table method from January 2019 to March 2021. The patients in the control group were treated with letrozole, and the patients in the observation group were treated with letrozole combined with tripreline. The ovulation effect on the day of ovulation induced, the pregnancy outcomes, and the levels of sex hormone, SHBG, and IGF-1 of the patients were compared between the two groups. Results: After treatment, the endometrial thickness and the number of mature follicles of the patients in the observation group were significantly higher than those of the patients in the control group. The ovulation rate(96.6%), the pregnancy rate(37.9%), the rate of ovarian cyst occurrence(1.7%), and the incidence of follicular hyperstimulation syndrome(0) of the patients in the observation group were significantly lower than those(72.4%, 20.7%, 13.8%, and 8.6%) of the patients in the control group. The levels of E_(2) of the patients in the observation group were significantly lower than those of the patients in the control group. The SHBG level(159.46±65.74 mmol/L) of the patients in the observation group was significantly higher than that(139.54±62.46 mmol/L) of the patients in the control group, but the IGF-1 level(270.78± 41.39μg/L) of the patients in the observation group was significantly lower than that(321.32± 62.95μg/L) of the patients in the control group(P<0.05).Conclusion:Letrozole combined with tripraline for treating the patients with PCOS complicated with ovulation disorders can increase their levels of sex hormone,SHBG,and
作者
王亚楠
李根霞
楚书慧
WANG Yanan;LI Genxia;CHU Shuhui(The Third Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province,450000)
出处
《中国计划生育学杂志》
2022年第5期1009-1012,共4页
Chinese Journal of Family Planning
