摘要
目的探讨来曲唑联合定坤丹治疗不孕症的临床效果及对患者妊娠情况、子宫内膜厚度、性激素水平的影响。方法选择2018年10月至2019年9月于本院就诊的88例不孕症患者作为研究对象,根据随机数字表法将其分为对照组、观察组,各44例。对照组给予来曲唑治疗,观察组给予来曲唑联合定坤丹治疗。比较两组的性激素[促卵泡激素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))、孕酮(P)]水平、卵巢体积、子宫内膜厚度、排卵情况(卵泡生长时间、排卵数、优势卵泡数)、子宫内膜血流参数[搏动指数(PI)、阻力指数(RI)]、临床疗效、不良反应发生情况、妊娠情况。结果治疗后,两组的FSH、LH水平均降低,E_(2)、P水平均升高,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的卵巢体积均减小,子宫内膜厚度均增大,且观察组优于对照组,差异具有统计学意义(P<0.05)。观察组的卵泡生长时间短于对照组,排卵数、优势卵泡数多于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的PI、RI均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组的治疗总有效率为88.64%,显著高于对照组的70.45%,差异具有统计学意义(P<0.05)。观察组的不良反应总发生率为2.27%,显著低于对照组的15.91%,差异具有统计学意义(P<0.05)。观察组的自然妊娠率高于对照组,差异具有统计学意义(P<0.05)。结论来曲唑联合定坤丹治疗不孕症患者的效果显著,能够有效调节性激素水平,改善子宫内膜厚度,提高妊娠率。
Objective To explore the clinical effect of letrozole combined with Dingkundan in the treatment of infertility and its influences on pregnancy,endometrial thickness and sex hormone levels of patients.Methods A total of 88 patients with infertility treated in our hospital from October 2018 to September 2019 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 44 cases in each group.The control group was treated with letrozole,and the observation group was treated with letrozole combined with Dingkundan.The levels of sex hormones[follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),progesterone(P)],ovarian volume,endometrial thickness,ovulation(follicular growth time,ovulation number,number of dominant follicles),endometrial blood flow parameters[pulsatility index(PI),resistance index(RI)],clinical efficacy,occurrence of adverse reactions,and pregnancy were compared between the two groups.Results After treatment,the levels of FSH,LH in the two group decreased,the levels of E_(2) and P increased,and those in the observation group were better than the control group,the differences were statistically significant(P<0.05).After treatment,the ovarian volume decreased and endometrial thickness increased in the two groups,and those in the observation group were better than the control group,the differences were statistically significant(P<0.05).The follicular growth time of the observation group was shorter than that of the control group,and the ovulation number and the number of dominant follicles were more than those of the control group,the differences were statistically significant(P<0.05).After treatment,the PI and RI of the two groups decreased,and those of the observation group were lower than the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment of the observation group was 88.64%,which was significantly higher than 70.45%of the control g
作者
刘亚倩
刘英英
刘晓庆
LIU Yaqian;LIU Yingying;LIU Xiaoqing(Northwest Women's and Children's Hospital,Xi'an 710003,China)
出处
《临床医学研究与实践》
2022年第20期88-91,共4页
Clinical Research and Practice
关键词
不孕症
来曲唑
定坤丹
妊娠
子宫内膜厚度
性激素
infertility
letrozole
Dingkundan
pregnancy
endometrial thickness
sex hormone
