摘要
目的:探讨来曲唑联合高纯度尿促性素(HP-hMG)治疗对多囊卵巢综合征(PCOS)不孕患者妊娠效果的影响及激素调节作用机制。方法:选取2016年8月~2019年4月本院收治的132例PCOS不孕患者作为研究对象,采用随机数字表法分为研究组(来曲唑+HP-hMG)和对照组(来曲唑+二甲双胍),每组66例。对比两组干预前后血清雄激素(T)、黄体生成素(LH)、雌二醇(E_(2))、卵泡刺激素(FSH)、瘦素、胰岛素抵抗指数(HOMA-IR)、子宫内膜厚度、成熟卵泡数目、卵巢过度刺激综合征(OHSS)、排卵率、妊娠率、自然流产率。结果:治疗前,研究组和对照组的血清T、LH、E_(2)和FSH水平比较无统计学差异(P>0.05);治疗后,研究组的血清T低于对照组(P<0.05);E_(2)、LH和FSH水平与对照组比较无统计学差异(P>0.05)。治疗前,研究组和对照组的血清瘦素、HOMA-IR、子宫内膜厚度、成熟卵泡数目比较无统计学差异(P>0.05);治疗后,研究组的血清瘦素低于对照组(P<0.05),子宫内膜厚度、成熟卵泡数目高于对照组(P<0.05);治疗后,研究组的妊娠率(54.55%)高于对照组(33.33%,P<0.05);研究组和对照组的OHSS、排卵率、自然流产率比较无统计学差异(P>0.05)。结论:来曲唑联合HP-hMG治疗PCOS不孕患者,能较好地调节患者生殖激素、提高妊娠率。
Objective:To investigate the effect of letrozole and high purity-human menopausal gonadotropin(HP-hMG)on patients with infertile polycystic ovary syndrome(PCOS)and its mechanism of action.Methods:A total of 132 patients with PCOS infertility treated in our hospital from August 2016 to April 2019 were selected as the research subject,and divided into the study group(treated with letrozole+HP-hMG)and the control group(treated with letrozole+metformin)according to the random number table,66 cases in each group.Serum androgen(T),luteinizing hormone(LH),estradiol(E_(2)),follicle stimulating hormone(FSH),leptin,insulin resistance index(HOMA-IR),uterus intimal thickness,number of mature follicles,ovarian hyperstimulation syndrome(OHSS),ovulation rate,pregnancy rate,and spontaneous abortion rate were compared before and after intervention between the two groups.Results:Before treatment,the serum T,LH,E_(2) and FSH levels of the study group and the control group were not significantly different(P>0.05);after treatment,the serum T of the study group was lower than that of the control group(P<0.05);compared with the control group,the difference was not statistically significant in the levels of E2,LH and FSH(P>0.05).Before treatment,there was no significant difference in serum leptin,HOMA-IR,endometrial thickness,and number of mature follicles between the study group and the control group(P>0.05).After treatment,serum leptin in the study group was lower than that in the control group(P<0.05),and endometrial thickness and the number of mature follicles were higher than in the control group(P<0.05).After treatment,the pregnancy rate of the study group(54.55%)was higher than that of the control group(33.33%,P<0.05);there was no significant difference in OHSS rate,ovulation rate,and spontaneous abortion rate between the study group and the control group(P>0.05).Conclusion:Letrozole and HP-hMG can better regulate reproductive hormones and increase pregnancy rate in patients with PCOS infertility.
作者
杨永俊
李铭
曹丽幸
陈丹
吕永艳
张引引
YANG Yong-jun;LI Ming;CAO Li-xing;CHEN Dan;LV Yong-yan;ZHANG Yin-yin(Clinical Laboratory Center,Henan Provincial Maternity Hospital,Zhengzhou 450000,China)
出处
《中国合理用药探索》
2021年第9期85-89,共5页
Chinese Journal of Rational Drug Use
关键词
尿促性素
不孕
多囊卵巢综合征
来曲唑
生殖激素
human menopausal gonadotropin
infertility
polycystic ovary syndrome
letrozole
reproductive hormones
