摘要
目的:探讨免疫球蛋白联合美罗培南治疗新生儿败血症的临床效果。方法:选取2019年2月-2021年4月广州市白云区妇幼保健院收治的60例新生儿败血症患儿,按照随机数字表法将患儿分为观察组和对照组,每组30例。两组患儿均接受常规治疗,对照组在此基础上予以美罗培南,观察组在对照组的基础上加用免疫球蛋白。比较两组疗效、恢复情况、治疗前后炎症因子[白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]及免疫指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]水平。结果:观察组总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(P<0.05)。观察组拒奶改善时间、体温改善时间、皮肤颜色正常时间、血培养转阴时间及住院时间均短于对照组,差异均有统计学意义(P<0.05)。治疗后,两组IL-6、IL-1、hs-CRP、TNF-α水平均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组IgA、IgG、IgM水平均高于治疗前,且研究组均高于对照组,差异均有统计学意义(P<0.05)。结论:对新生儿败血症患儿予以免疫球蛋白联合美罗培南治疗可有效促进其病情好转,提高免疫功能,减轻机体炎症反应,疗效显著。
Objective:To investigate the clinical effect of Immunoglobulin combined with Meropenem in the treatment of neonatal septicemia.Method:A total of 60 children with neonatal septicemia admitted to Baiyun District Maternal and Child Health Hospital of Guangzhou City from February 2019 to April 2021 were selected,they were divided into observation group and control group according to random number table method,with 30 cases in each group.Both groups received conventional treatment,and the control group was given Meropenem on this basis,while the observation group was given Immunoglobulin on the basis of the control group.Efficacy,recovery,levels of inflammatory factors[interleukin-1 (IL-1),interleukin-6 (IL-6),high sensitivity C reactive protein (hs-CRP),tumor necrosis factor-α (TNF-α)]and immune indexes[immunoglobulin A (IgA),immunoglobulin G (IgG),immunoglobulin M (IgM)]before and after treatment were compared between two groups.Result:The total effective rate of observation group was 93.33%,which was higher than 73.33% of the control group,the difference was statistically significant (P<0.05).The improvement time of milk rejection,body temperature,skin color for normal time,blood culture to negative and hospital stay in the observation group were shorter than those in the control group,the differences were statistically significant (P<0.05).After treatment,the levels of IL-6,IL-1,hs-CRP and TNF-α of both groups were lower than those before treatment,and those of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).After treatment,the levels of IgA,IgG and IgM of both groups were higher than those before treatment,and those of the observation group were higher than those of the control group,the differences were statistically significant (P<0.05).Conclusion:The treatment of neonatal septicemia with Immunoglobulin combined with Meropenem can effectively promote the improvement of the condition,improve the immune function and reduce the inflammator
作者
梁颖娜
张慧珊
李志涛
LIANG Yingna;ZHANG Huishan;LI Zhitao(Baiyun District Maternal and Child Health Hospital of Guangzhou City,Guangzhou 510410,China;不详)
出处
《中国医学创新》
CAS
2022年第11期69-72,共4页
Medical Innovation of China
