摘要
目的:探讨免疫球蛋白联合抗菌药物在新生儿败血症治疗中的临床效果。方法:选取笔者所在医院2018年1月-2019年4月收治的新生儿败血症患儿54例,按照随机数字表法分为对照组和观察组,每组27例。两组均对症治疗,同时对照组给予美罗培南治疗,观察组在对照组用药基础上静脉滴注免疫球蛋白。统计两组血小板(PLT)、血白细胞计数恢复正常时间及住院时间;观察两组治疗前后IgA、IgG等免疫功能指标变化情况并评估其IL-6、hs-CRP水平;观察药物不良反应情况。结果:观察组PLT、血白细胞计数恢复正常时间及住院时间均短于对照组,差异均有统计学意义(P<0.01)。治疗前两组IgA、IgG及IL-6、hs-CRP水平比较差异无统计学意义(P>0.05);治疗后观察组IgA、IgG水平均高于治疗前及对照组,IL-6、hs-CRP水平均低于治疗前及对照组,差异均有统计学意义(P<0.05);对照组治疗前后IgA、IgG水平比较差异无统计学意义(P>0.05)。观察组不良反应发生率11.1%,对照组为7.4%,差异无统计学意义(P>0.05)。结论:免疫球蛋白联合抗菌药物治疗早产儿败血症,有助于促进患儿症状改善、提高免疫功能并降低炎症反应,且安全性较高,有较高的应用价值。
Objective: To explore the clinical effect of immunoglobulin combined with antibiotics in the treatment of neonatal sepsis. Method: A total of 54 neonatal septicemia admitted to our hospital from January 2018 to April 2019 were selected. According to the random number table method, the patients were divided into the control group and the observation group, 27 cases in each group. Both groups were treated symptomatically, while the control group was treated with meropenem. The observation group was given intravenous immunoglobulin on the basis of the control group. The time of recovery of the platelet(PLT) level, the white blood cell count, and hospitalization time in the two groups were counted. The changes of immune function indexes such as IgA and IgG were observed before and after treatment, and the levels of IL-6 and hs-CRP were evaluated. The adverse drug reactions were observed. Result: The time of recovery of the platelet(PLT) level, the white blood cell count, and hospitalization time in the two groups were in the observation group were shorter than those in the control group(P<0.01). There was no significant difference in the levels of IgA, IgG and IL-6, hs-CRP between the two groups before treatment(P>0.05). After treatment, the level of IgA, IgG in the observation group were higher those that before treatment and in the control group, and the level of IL-6, hs-CRP in the observation group were lower than those before treatment and in the control group, the differences were statistically significant(P<0.05). There were no significant changes in IgA and IgG immune function indexes in the control group before and after treatment(P>0.05). The incidence of adverse reactions was 11.1% in the observation group and 7.4% in the control group, there was no statistically significant difference(P>0.05). Conclusion: Immunoglobulin combined with antibiotics in the treatment of premature infants with sepsis can help to improve symptoms, improve immune function and reduce inflammatory response, and has high safety, whi
作者
刘春花
万致婷
LIU Chunhua;WAN Zhiting(Xianning Central Hospital,Xianning 437000,China)
出处
《中外医学研究》
2019年第33期53-55,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
