摘要
目的探讨延长美罗培南静脉滴注时间对新生儿晚发型败血症的疗效和安全性。方法将120例晚发型败血症新生儿随机分为静注3 h组及静注30 min组各60例,均给予美罗培南[20 mg/(kg·次),1次/8 h],静脉滴注时间分别为3 h和30 min。记录患儿临床症状缓解所需时间,比较治疗前、治疗1周两组的血常规、C反应蛋白(CRP)及钙素原(PCT)水平,以及死亡情况及使用辅助通气治疗情况。观察两组不良反应发生情况。结果治疗后,两组的WBC计数、中性粒细胞比例、CRP及PCT水平均较前下降(均P<0.05),且静注3 h组低于静注30 min组(均P<0.05)。静注3 h组临床症状缓解时间短于静注30 min组,死亡比例及辅助通气比例低于静注30 min组(均P<0.05)。治疗前后两组ALT、AST、尿素氮、肌酐水平均在正常范围内,差异均无统计学意义(均P>0.05)。结论对于新生儿晚发型败血症,美罗培南静脉滴注3 h的疗效优于静注30 min,且不增加不良反应的发生。
Objective To explore the efficacy and safety of prolonged intravenous infusion duration of meropenem for neonatal late-onset sepsis. Methods One hundred and twenty neonates with late-onset sepsis were randomly divided into 3-hour group and 30-minute group,with 60 cases in each group. The two groups were administered meropenem（ 20 mg/kg per time,every 8 hours） for intravenous infusion durations of 3 hours and 30 minutes respectively. The duration for clinical symptoms remission was recorded. The levels of complete blood cell count,C-reactive protein（ CRP） and procalcitonin（ PCT） before treatment and after one week of treatment,death and application of assisted ventilation therapy were compared between the two groups. The incidence of adverse effects was observed in both groups. Results After treatment,the WBC count,proportion of neutrophil granulocyte,levels of CRP and PCT in both groups decreased compared to the levels before treatment（ all P 0. 05）,and the levels in the 3-hour group were lower than those in the 30-minute group（ all P 0. 05）. In the 3-hour group,the duration for clinical symptoms remission was shorter,the proportions of death and cases using assisted ventilation therapy were lower compared to the 30-minute group（ all P 0. 05）. The levels of ALT,AST,urea nitrogen and creatinine in both groups were within normal limits,and no significant differences in those indices between the two groups（ all P 0. 05）. Conclusion For neonatal late-onset sepsis,the intravenous administration of meropenem for 3 hours can achieve better efficacy compared to the intravenous administration for 30 minutes,and does not increase the incidence of adverse effects.
出处
《广西医学》
CAS
2018年第4期372-374,共3页
Guangxi Medical Journal
基金
安徽省自然科学基金(1308085MH150)
安徽省高等学校省级自然科学研究项目(KJ2013A167)
关键词
败血症
晚发型
美罗培南
新生儿
疗效
安全性
静脉滴注时间
Sepsis, Late-onset, Meropenem, Neonates, Efficacy, Safety, Intravenous infusion duration
