摘要
探讨万古霉素联合丙种球蛋白治疗新生儿败血症的临床疗效及对血小板以及胆红素的影响。选取该院2017年1月至2019年1月收治的符合入选标准的新生儿败血症患儿84例为观察对象,数字法随机将其分为对照组(n=42例)与试验组(n=42例),两组均给予患者维持水电解质平衡等常规治疗,对照组在其前提下给予患者利奈唑胺治疗,试验组则在常规基础上给予患者万古霉素联合丙种球蛋白治疗。观察比较两组患者拒奶、神经系统等症状指标、住院时间、临床疗效、免疫学指标血清免疫球蛋白G(Ig G)、免疫球蛋白M(Ig M)、自然杀伤细胞(NK细胞)活性,同时比较两组患者的总胆红素以及血小板计数,并观察两组不良反应情况。试验组患者症状改善以及住院时间均短于对照组(P <0. 05);试验组患者的临床治疗总有效率为92. 86%,高于对照组的73. 81%(P <0. 05);试验组患者的Ig G、NK细胞高于对照组,而Ig M明显低于对照组(P <0. 05);试验组患者的总胆红素低于对照组,而血小板计数高于对照组(P <0. 05);两组不良反应发生率比较差异无统计学意义(P> 0. 05)。万古霉素联合丙种球蛋白可以明显改善新生儿败血症患儿临床症状,缩短住院时间,提高疗效,并可调节机体免疫水平,稳定血小板及总胆红素,具良好临床应用价值。
To investigate the clinical effect of vancomycin combined with gamma globulin in the treatment of neonatal sepsis and its effect on platelets and bilirubin,84 neonatal sepsis patients admitted to the author’s hospital from January 2017 to January 2019 who met the inclusion criteria were selected as the observation objects;they were randomly divided into control group( n = 42 patients)and experimental group( n = 42 patients) by numerical method;both groups were given routine treatment such as maintaining water and electrolyte balance,the control group was treated with linidazolamide,while the experimental group was treated with vancomycin combined with gamma globulin on a routine basis. The author compared two groups of patients from milk,neurological symptoms such as index,the length of time,clinical curative effect and immunological indexes of serum immunoglobulin G( Ig G),immunoglobulin M( Ig M),natural killer cells( NK cells) activity;at the same time compared two groups of patients in total bilirubin and platelet count,and observed two groups in adverse reactions. The improvement of symptoms and length of stay in the experimental group were shorter than those in the control group( P < 0. 05). The total clinical effective rate of the experimental group was 92. 86%,higher than 73. 81% of the control group( P < 0. 05). Ig G and NK cells in the experimental group were higher than those in the control group,while Ig M was significantly lower than that in the control group( P < 0. 05). The total bilirubin in the experimental group was lower than that in the control group,while the platelet count was higher than that in the control group( P < 0. 05). There was no statistically significant difference in the incidence of adverse reactions between the two groups( P > 0. 05). Vancomycin combined with gamma globulin can significantly improve the clinical symptoms of neonatal sepsis,shorten the length of hospital stay,improve the efficacy,regulate the immune level of the body,stabilize platelets and total bilirubin. So
作者
黄晨露
林振浪
瞿尔力
HUANG Chen-lu;LIN Zhen-lang;QU Er-li(Department of Neonatology, The No.2 Affiliated Hospital of Wenzhou Medical University and Yuying Children's Hospital, Wenzhou 325000, China;Clinical School of Theorem of Wenzhou Medical University and Neonatal Department of Wenzhou Central Hospital, Wenzhou 325000, China)
出处
《药物生物技术》
CAS
2019年第3期240-243,共4页
Pharmaceutical Biotechnology
