摘要
目的：观察头孢噻肟联合丙种球蛋白治疗新生儿败血症临床疗效及对CRP、PCT、CD64水平的影响，为临床治疗提供参考。方法：回顾性分析我院2012年1月至2014年10月接诊的120例新生儿败血症患儿的临床资料，根据治疗方法分为观察组64例和对照组56例，两组均给予对症、支持治疗，对照组再给予头孢噻肟（凯福隆）100mg／（kg·d）分2次静脉滴注，观察组在对照组治疗基础上再静脉注射丙种球蛋白400mgr／（kg·d），每天1次，疗程3～5d。比较两组患儿的临床症状（拒奶、神经系统症状、体温）改善时间、住院时间、病死率，治疗前、治疗后1周检测血清CRP和血清PCT水平，采用流式细胞术测定中性粒细胞CD64水平，进行临床疗效评价。结果：（1）观察组拒奶改善时间、神经系统症状改善时间、体温改善时间、住院时间均明显短于时照组（t分别为3．413、3．507、3．623、3．863，P均〈0．05）。（2）观察组和对照组治疗后血清CRP、血清PCT、中性粒细胞CD64水平均较治疗前明显下降（t分别为8．215和5．036、7．554和4．805、10．202和6．316，P均〈O．05），观察组治疗后血清CRP、血清PCT、中性粒细胞CD64水平明显低于对照组（￡分别为3．316、3．776、3．826，P均〈O．05）。（3）观察组的临床疗效明显高于对照组，病死率明显低于对照组（P〈0．05）。结论：头孢噻肟联合丙种球蛋白治疗新生儿败血症的临床疗效确切，与单纯头孢噻肟治疗比较能有效提高临床疗效，降低病死率，这可能与其对抗炎症反应及增强抵御感染作用有关。
Objective： To observe the effect and influence on CRP, PCT, CD64 in the treatment of neonatal sepsis by gamma globulin and cefotaxime, and provide reference for clinical treatment. Methods： Made a retrospective analysis of the clinical data of 120 neonatal sepsis in our hospital from January 2012 to October 2014, All the children were divided into 64 cases of observation group and 56 cases of control group, both groups were given symptomatic and supportive treatment, then the control group were received cefotaxime 100 mg/（kg ~ d） which were divided 2 doses by intravenous drip, the observation group were received gamma globulin 400 mg/（ kg ~ d）, once a day, 3 -5 days for a course. The symptoms improvement time, hospital stay time, mortality were compared to evaluate efficacy, the blood were phlehotomized for detecting the CRP and PCT, the neutrophil CD64 were detected by flow cytometry. Results： （1） The improve time of refusing milk, neurological symptoms, temperature, and hospital stay time in observation group were significantly shorter than the control group （t=3. 413, 3. 507, 3. 623, 3. 863, P〈0.05）. （2） The serum CRP, PCT and neutrophil CD64 of observation group and control group after treatment were lower than before treatment （t = 8.215 and 5. 036, 7. 554 and 4. 805, 10, 202 and 6. 316, P〈0. 05 ）, the serum CRP, PCT and neutrophil CD64 of observation group after treatment were lower than control group （ t = 3.316, 3.776, 3.826, P〈0. 05 ）. （3） The clinical efficacy of observation group was significantly higher than the control group, the difference was statistically significant （P〈0. 05）, the mortality was significantly lower than the control group （P〈0. 05 ）. Conclusion： The method containing gamma globulin and cefotaxime have exact efficacy, can improve the clinical efficacy of antibiotic therapy, and reduce the mortality, which may be relate to its strong anti-inflammatory and anti-infection.
出处
《儿科药学杂志》
CAS
2015年第6期21-23,共3页
Journal of Pediatric Pharmacy
