摘要
目的探讨替格瑞洛片在治疗冠心病心绞痛的临床效果。方法方便选取2017年1月—2018年1月该院收治的急性心绞痛患者100例为研究对象,采用随机数字表法进行分组,分为观察组(n=50)和常规组(n=50);常规组给予常规性用药治疗,观察组则在常规组的基础上增用替格瑞洛片进行治疗。两组患者均持续接受3个月的治疗。对比两组患者的凝血指标变化、临床治疗总有效率及药物不良反应占比进行比较两组患者给予药物治疗后的疗效变化。结果两组给予药物治疗后,两组凝血指标中PT、FBG、APTT及PAgT较治疗前均有明显降低,TT均明显升高均较治疗前有明显改善;成组比较差异有统计学意义(P<0.05)。其中观察组PAgT优于常规组(39.12±8.42)%vs(29.12±6.94)%(P<0.05),观察组(94.00%)临床有效率高于常规组(78.00%)且差异有统计学意义(χ^2=5.316,P=0.021),两组不良反应发生率差异无统计学意义(χ^2=0.709,P=0.400)。结论替格瑞洛片在冠心病心绞痛治疗应用上有很好的临床效果,且不增加药物不良反应,安全性较高。
Objective To explore the clinical effect of ticagrelor tablets in the treatment of coronary heart disease and angina pectoris.Methods 100 patients with acute angina pectoris treated in the hospital from January 2017 to January 2018 were convenient selected as the research subjects.They were divided into two groups using the random number table method and divided into the observation group(n=50)and the conventional group(n=50);the conventional group was given conventional medication,while the observation group was treated with ticagrelor tablets on the basis of the conventional group.Both groups of patients continued to receive treatment for 3 months.The changes of coagulation index,the total effective rate of clinical treatment and the proportion of adverse drug reactions were compared between the two groups of patients.Results After the two groups were given drug treatment,PT,Fbg,APTT,and PAgT in the two groups were significantly lower than before treatment,and the TT was significantly increased and significantly improved than before treatment.The difference between the groups was statistically significant(P<0.05).The PAgT of the observation group were better than those of the conventional group(39.12±8.42)%VS(29.12±6.94)%,P<0.05.The clinical effectiveness of the observation group(94.00%)was higher than that of the conventional group(78.00%)and had statistical differences(χ^2=5.316,P=0.021).There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ^2=0.709,P=0.400).Conclusion Tigrelor tablets have a good clinical effect in the treatment of coronary heart disease and angina pectoris.It does not increase the adverse drug reactions and has high safety.
作者
章钦
ZHANG Qin(Department of Cardiology,the Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui Province,230000 China)
出处
《中外医疗》
2020年第7期113-115,共3页
China & Foreign Medical Treatment
关键词
替格瑞洛
心绞痛
治疗总有效率
凝血指标
心绞痛频率
Ticagrelor
Angina pectoris
Total effective rate of treatment
Coagulation index
Angina pectoris frequency
