摘要
目的:探讨芪参益气滴丸联合地尔硫[艹卓]治疗变异型心绞痛的疗效及对血清内皮素-1(ET-1)、一氧化氮(NO)及心肌肌钙蛋白Ⅰ(cTnⅠ)水平的影响。方法:选取2019年12月~2021年12月于某院治疗的126例变异型心绞痛患者作为研究对象,采用随机数字表法分为对照组和观察组,每组64例。两组患者入院后均给予抗血小板聚集、调血脂、降血压等常规基础治疗,对照组在此基础上口服盐酸地尔硫[艹卓]片,观察组在对照组基础上联用芪参益气滴丸,均持续治疗4周。比较两组患者心功能指标[左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)和左室射血分数(LVEF)]及血清NO、ET-1、cTnⅠ水平变化,临床疗效及临床症状情况。结果:治疗后,两组患者LVESD和LVEDD值较治疗前均降低(P<0.05),LVEF较治疗前升高(P<0.05),且观察组改善更显著(P<0.05);两组血清ET-1和c TnⅠ水平较治疗前均降低(P<0.05),NO水平较治疗前升高(P<0.05),且观察组改善更显著(P<0.05);观察组心绞痛疗效和心电图疗效较对照组升高(P<0.05);两组患者心绞痛发作频率和疼痛持续时间较治疗前均降低(P<0.05),且观察组降低更显著(P<0.05)。结论:地尔硫[艹卓]联合芪参益气滴丸对变异型心绞痛具有较好的临床疗效,可有效降低血清ET-1、NO及cTnⅠ水平,值得临床推广应用。
Objective:To investigate the efficacy of Qishen Yiqi droplet combined with diltiazem in the treatment of variant angina pectoris and its effect on the levels of serum endothelin-1(ET-1),nitric oxide(NO)and cardiac troponinⅠ(cTnⅠ).Methods:A total of 126 patients with variant angina pectoris treated in our hospital during December 2019 to December 2021 were divided into control group(n=64)and observation group(n=64)by random number table.After admission,the two groups were given conventional basic treatment including platelet aggregation inhibitors,lipid-lowering drugs,and antihypertensive agents,etc.In addition,The control group was treated with diltiazem hydrochloride tablets,and the observation group was treated with Qishen Yiqi droplet in addition to the control treatment,and the treatment lasted for 4 weeks.The cardiac function indicators[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)],the changes in the levels of serum NO,ET-1 and cTnⅠ,clinical efficacy and clinical symptoms were compared between the two groups.Results:After treatment,Both LVESD and LVEDD were decreased(P<0.05)and LVEF was increased(P<0.05)in both groups compared to those before treatment,and the improvement was more significant in the observation group(P<0.05).The levels of serum ET-1 and cTnⅠin both groups were lower than before treatment(P<0.05),and NO levels were higher than before treatment(P<0.05),and the improvement was more significant in the observation group(P<0.05).The response of the observation group was improved compared with that in the control group in terms of the angina pectoris and electrocardiogram(P<0.05).The frequency of angina pectoris attack and the duration of pain were decreased in both groups compared to those before treatment(P<0.05),and the decrease was more significant in the observation group(P<0.05).Conclusion:Diltiazem combined with Qishen Yiqi droplet has favorable clinical efficacy in the treatment of variant angin
作者
李华政
史尊基
夏树涛
LI Hua-zheng;SHI Zun-ji;XIA Shu-tao(Department of Cardiovascular Medicine,General Hospital of Hebi Coal Industry(Group)Company,Hebi 458000,China;Department of Laboratory,General Hospital of Hebi Coal Industry(Group)Company,Hebi 458000,China)
出处
《中国合理用药探索》
CAS
2023年第8期78-83,共6页
Chinese Journal of Rational Drug Use
