摘要
目的 分析替格瑞洛片治疗复杂冠心病的临床疗效。方法 100例复杂冠心病患者,采用计算机分组方法分为观察组和对照组,每组50例。两组均完善检查采取经皮冠状动脉介入术治疗,对照组采用氯吡格雷治疗,观察组采用替格瑞洛片治疗。比较两组心功能指标水平、服药后不良反应发生情况、预后转归情况。结果 治疗前,两组左室射血分数、左室舒张末期内径水平比较差异无统计学意义(P>0.05);治疗后,观察组患者左室射血分数(57.22±3.50)%高于对照组的(48.36±4.16)%,左室舒张末期内径(53.29±1.70)mm小于对照组的(58.41±1.89)mm,差异具有统计学意义(P<0.05)。两组患者服药后均未出现严重不良反应,仅少数患者出现心律失常、呼吸困难、出血症状,两组不良反应发生率比较差异无统计学意义(P>0.05)。两组患者均获得完整随访,观察组血栓形成率6.0%、脑卒中率0以及死亡率4.0%均明显低于对照组的20.0%、12.0%、16.0%,差异具有统计学意义(P<0.05)。结论 复杂冠心病患者采用替格瑞洛片治疗能够有效改善患者病情,促进心功能恢复,有利于疾病转归,而且用药安全性高,值得在临床治疗中继续推广使用。
Objective To analyze the clinical efficacy of ticagrelor tablets in the treatment of complex coronary heart disease.Methods 100 patients with complex coronary artery disease were divided into an observation group and a control group by computer grouping method,with 50 patients in each group.Both groups were examined and treated with percutaneous coronary intervention.The control group was treated with clopidogrel,and the observation group was treated with ticagrelor tablets.Levels of cardiac function index,incidence of adverse reactions after administration,prognosis and outcome were compared between these two groups.Results Before treatment,differences in left ventricular ejection fraction and left ventricular end-diastolic diameter in both groups were not statistically significant(P>0.05);after treatment,the left ventricular ejection fraction in the observation group was(57.22±3.50)%,which was higher than(48.36±4.16)%in the control group,and the left ventricular end-diastolic diameter in the observation group was(53.29±1.70)mm,which was less than(58.41±1.89)mm in the control group,and the difference was statistically significant(P<0.05).Patients in both groups showed no adverse reactions after administration,with only a small number of patients had arrhythmia,breathing difficulties and bleeding,while difference in incidence of adverse reactions in these two groups was not statistically significant(P>0.05).Patients in both groups received complete follow-up.The observation group had thrombosis rate of 6.0%,stroke rate of 0,and mortality rate of 4.0%,which were significantly lower than corresponding 20.0%,12.0%and 16.0%in the control group,and the difference was statistically significant(P<0.05).Conclusion Adiministration of ticagrelor tablets in the treatment of patients with complex coronary heart disease can effectively improve the patient’s conditions,promote the recovery of cardiac functions,and it is conducive to the outcome,with high safety.Thus,it is worth continuous promoting in clinical practice.
作者
张钧伟
李今朝
李克研
ZHANG Jun-wei;LI Jin-zhao;LI Ke-yan(Department of Cardiovascular Internal Medicine,First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,China)
出处
《中国实用医药》
2021年第22期1-4,共4页
China Practical Medicine
关键词
替格瑞洛片
复杂冠心病
心功能
不良反应
临床疗效
预后
Ticagrelor tablet
Complex coronary heart disease
Cardiac function
Adverse reactions
Clinical efficacy
Prognosis
