摘要
目的:探讨神经节苷脂钠对颅内出血早产儿神经功能恢复及后遗症的影响。方法:早产儿颅内出血的患儿60例,随机分为两组,每组30例。对照组采用基础对症支持治疗,观察组在对照组的基础上加用单唾液酸四己糖神经节苷脂钠治疗。治疗前后行CT检查,评估脑血肿的吸收情况;在治疗前和治疗7d后,测定患儿的凝血功能[D-二聚体(D-D)、血小板(PLT)]、pH值,根据新生儿行为神经测定量表(NBNA)评分对患儿神经功能进行评估;记录两组治疗过程中并发症发生情况;随访6个月,比较两组患儿后遗症发生情况。结果:治疗7d后,观察组患儿颅内血肿体积比对照组更小,NBNA评分在观察组中更高,但并发症发生率则更低(均P<0.05);D-D值在观察组中更低,PLT值在观察组更高(均P<0.05);观察组PHpH值更高(P<0.05),但在正常范围;随访6个月后,观察组患儿后遗症发生率更低(P<0.05)。结论:神经节苷脂钠能促进颅内出血早产儿神经功能恢复,促进颅内血肿吸收,减少后遗症发生率。
Objective:To investigate the effects of ganglioside sodium on neurological function recovery and sequelae in premature infants with intracranial hemorrhage.Methods:A total of 60 premature infants with intracranial hemorrhage were randomly divided into two groups,with 30 cases in each group.The control group was treated with basic symptomatic support,while the observation group was treated with monosialotetrahexosyl ganglioside sodium on the basis of the control group.CT examination was performed before and after treatment to evaluate the absorption of cerebral hematoma.Coagulation function[D-dimer(D-D),platelet(PLT)]and pH were measured 7 days before and after treatment.Neurological function of the children was evaluated according to the neonatal behavioral neurometry scale(NBNA)score.The incidence of sequelae was compared between the two groups after 6 months of follow-up.Results:After 7 days of treatment,the volume of intracranial hematoma in the observation group was smaller than that in the control group,and the NBNA score was higher in the observation group,but the incidence of complications was lower(P<0.05),the D-D value was lower in the observation group,and the PLT value was higher in the observation group(P<0.05),the pH value in the observation group was higher(P<0.05),but in the normal range.After 6 months of the follow-up,the incidence of sequelae in the observation group was lower(P<0.05).Conclusion:Ganglioside sodium can promote the recovery of nerve function in premature infants with intracranial hemorrhage,promote the absorption of intracranial hematoma and reduce the incidence of sequelae.
作者
郄学敏
霍耀
葛蕾萱
季珊
马欢欢
田敬茹
郭战坤
阴艳红
QIE Xue-min;HUO Yao;GE Lei-xuan;JI Shan;MA Huan-huan;TIAN Jing-ru;GUO Zhan-kun;YIN Yan-hong(Department of Paediatrics,1.Baoding Maternal and Child Health Hospital;People's Hospital of Rongcheng,Baoding 071700,Hebei,China)
出处
《川北医学院学报》
CAS
2019年第5期574-577,共4页
Journal of North Sichuan Medical College
基金
河北省保定市科技项目(18ZF301)
关键词
神经节苷脂钠
颅内出血
早产儿
神经功能
后遗症
Ganglioside sodium
Intracranial hemorrhage
Premature infant
Neurological function
Sequelae
