摘要
目的探讨神经节苷脂治疗早产儿颅内出血所致神经系统损伤的临床疗效。方法选取2018年3月至2020年5月本院收治的120例早产儿颅内出血所致神经系统损伤患儿作为研究对象,根据治疗方法不同分为对照组与观察组,每组60例。对照组给予常规对症支持治疗及干预,观察组在对照组治疗基础上给予神经节苷脂治疗,比较两组临床疗效、治疗前后神经行为测定(NBNA)评分及颅内情况、运动异常情况、早产儿不良结局。结果观察组治疗总有效率为93.33%,高于对照组的75.00%,差异有统计学意义(P<0.05)。两组神经行为评分组间、时间、交互比较差异有统计学意义(P<0.05);两组治疗后各时间点神经行为评分均高于前一时间点,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组颅内血肿体积、pH值比较差异无统计学意义;治疗后,两组颅内血肿体积均小于治疗前,pH值均高于治疗前,且观察组颅内血肿体积均小于对照组,pH值均高于对照组(P<0.05)。观察组运动异常发生率为3.33%,低于对照组的21.67%,差异有统计学意义(P<0.05)。观察组早产儿不良结局发生率为3.33%,低于对照组的15.00%,差异有统计学意义(P<0.05)。结论神经节苷脂治疗早产儿颅内出血所致神经系统损伤疗效显著,可明显改善早产儿神经功能,减少运动功能异常发生,降低不良结局发生率,值得临床推广应用。
Objective To investigate the clinical efficacy of ganglioside in the treatment of nervous system injury caused by intracranial hemorrhage in premature infants.Methods 120 children with nervous system injury caused by intracranial hemorrhage in premature infants admitted to our hospital from March 2018 to May 2020 were selected as the research subjects,they were divided into control group and observation group according to different treatment methods,with 60 cases in each group.The control group was given routine symptomatic support treatment and intervention,while the observation group was given ganglioside treatment on the basis of the control group,the clinical efficacy,neonatal behavioral neurological assessment(NBNA)score before and after treatment,intracranial condition,abnormal movement and adverse outcome of premature infants were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%,which was higher than 75.00%in the control group,and the difference was statistically significant(P<0.05).There were significant differences in neurobehavioral scores between the two groups,time and interaction(P<0.05).The neurobehavioral scores of the two groups at each time point after treatment were higher than those at the previous time point,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in intracranial hematoma volume and pH value between the two groups;after treatment,the intracranial hematoma volume of the two groups was smaller than that before treatment,and the pH value was higher than that before treatment,and the intracranial hematoma volume in the observation group was smaller than that in the control group,and the pH value was higher than that in the control group(P<0.05).The incidence of abnormal movement of premature infants in the observation group was 3.33%,which was lower than 21.67%in the control group,and the difference was stat
作者
刘子丽
武琨
LIU Zii;WU Kun(Department of Neonatology,Fuxin Second People's Hospital,Fuxin Maternity and Obstetrics Hospital,Fuxin,Liaoning,123000,China)
出处
《当代医学》
2023年第3期36-39,共4页
Contemporary Medicine
关键词
神经节苷脂
早产儿
颅内出血
神经系统损伤
Ganglioside
Premature infant
Intracranial hemorrhage
Nervous system injury
