摘要
目的检测活化的白细胞粘附分子(ALCAM)在早期子宫内膜样子宫内膜癌的表达情况,探讨ALCAM与该病的进展及预后的关系。方法采用免疫组织化学和荧光定量聚合酶链式反应(RT-PCR)检测105例子宫内膜样子宫内膜癌组织和癌旁组织中ALCAM的表达水平,分析不同分期、浸润深度病例ALCAM的表达差异,及其与疾病预后的关系。结果 ALCAM在早期癌组织中的表达量明显高于癌旁组织(P <0. 05),随着肌层浸润深度增加,其表达有增加的趋势。Cox比例风险回归模型分析显示:淋巴结阳性、ALCAM和肿瘤大小是影响早期子宫内膜样子宫内膜癌总体生存时间预后的独立危险因素。结论 ALCAM可能与早期子宫内膜样子宫内膜癌的疾病进展密切相关,其高表达可能促进癌细胞的侵袭转移,可能预示疾病的预后不佳。
Objective To investigate the expression of ALCAM in early endometrial carcinoma and to explore the relationship between ALCAM and progression and prognosis of ALCAM. Methods Immunohistochemical method and RT-PCR were used to detect the expression of ALCAM in 105 cases of endometrioid endometrial carcinoma and adjacent tissues. The relationship between the expression of ALCAM and the progression of disease was analyzed. Results The expression of ALCAM in early cancer tissues was significantly higher than that in adjacent tissues （ P 〈0.05）. The expression of ALCAM increased with the increase of myometrial invasion depth. Cox proportional hazards regression analysis showed that lymph node positive, ALCAM and tumor size were independent risk factors for the overall survival time of early endometrial endometrial carcinoma. Conclusion ALCAM may be closely related to the progression of early endometrioid endometrial carcinoma, and its high expression may promote the invasion and metastasis of cancer cells, which may indicate the poor prognosis of the disease.
作者
田艺
张坤
杨瑾
赵静
TIAN Yi ;ZHANG Kun ;YANG Jin ;et al.(Department of Obstetrics and Gynecology, The Fourth Hospital of Xi＇an, Xi＇an Shaanxi 710004, China;Department of Obstetrics and Gynecology, the Fourth Hospital of Xi＇an, Xi＇an Shaanxi 710004, China)
出处
《临床和实验医学杂志》
2018年第21期2297-2300,共4页
Journal of Clinical and Experimental Medicine
