摘要
β2微球蛋白（β2-MG）在正常机体的组织和细胞中表达水平低,而在肿瘤组织和细胞中表达水平升高,主要功能是参与调控肿瘤细胞中信号传导,促进肿瘤细胞生长及血管生成,并且与肿瘤的发生、发展、转移及预后相关,可作为肿瘤判断预后的重要指标.目前已在多种肿瘤细胞中证实,以β2-MG为靶点的抗肿瘤药物有望成为肿瘤新一代的靶向药物.
Beta 2-microglobulin （β2-MG） has low expression levels in tissues and cells of normal organisms, but its expression levels is increasing in tumor. The main function of β2-MG is to regulate signal transduction in tumor cells and promote tumor cell growth and angiogenesis. High level expression of β2-MG is associated with the occurrence, progression, metastasis and prognosis of human tumors and can serve as an independent indicator of tumor prognosis. It has been confirmed in a variety of tumor cells that agent targeting β2-MG is expected to become a new generation of targeted drugs.
作者
王娟
钟春生
张朝阳
Wang Juan, Zhong Chunsheng, Zhang Chaoyang(Department of Oncology, Third People＇s Hospital of Bengbu, Affiliated to Bengbu Medical College, Bengbu 233000, China)
出处
《国际肿瘤学杂志》
CAS
2018年第7期423-426,共4页
Journal of International Oncology
关键词
Β2微球蛋白
肿瘤
预后
Beta 2-microglobulin
Neoplasms
Prognosis
