摘要
目的探讨薯蓣膏联合西药治疗老年高血压的临床疗效及对患者血压变异性和尿微量白蛋白(mALb)、β_2微球蛋白(β_2-MG)水平的影响。方法选择2015年6月～2017年1月我院收治的60例老年高血压患者作为研究对象,随机分为观察组(n=30)及对照组(n=30)。对照组常规给予西药降压治疗,观察组在对照组治疗基础上服用薯蓣膏治疗,对比两组患者的降压临床疗效、中医症候疗效和不良反应,检测并比较两组治疗前后的颈动脉内膜-中层厚度、mALb、β_2-MG水平以及血压变异系数。结果观察组降压总有效率为90.00%,对照组总有效率为80.00%,差异无统计学意义(P>0.05)。观察组中医证候总有效率为90.00%,高于对照组总有效率的66.67%(P<0.05)。治疗后,观察组颈动脉内膜-中层厚度、mALb、β_2-MG水平以及24 h、白昼和夜间的收缩压变异系数(SBPV)、舒张压变异系数(DBPV)较对照组降低(P<0.05)。两组治疗后均未见明显不良反应。结论薯蓣膏联合西药治疗老年高血压患者疗效显著,可明显地降低颈动脉内膜-中层厚度、减少尿蛋白的渗出,并改善血压变异系数,且安全性较好。
Objective To investigate the clinical efficacy of dioscorea opposita cream combined with western medicine in the treatment of elderly hypertension and its influenee on blood pressure variability and urinary mieroalbumin （mALb）and β2 mieroglobulin（β2-MG） levels. Methods Sixty elderly patients with hypertension who were admitted to our hospital from June 2015 to January 2017 were randomly divided into observation group （n=30） and control group （n=30）. The control group was routinely given western medicine antihypertensive treatment. The observation group was treated with Dioseorea opposita cream based on the treatment of the control group. The clinical efficacy, TCM symptom efficacy and adverse reactions between the two groups were compared. The carotid intima-media thickness, mALb, β2- MG levels, and blood pressure variation coefficient between two groups before and afler treatment were detected and compared. Results The total effective rate of antihypertension in the observation group was 90.00%, which was 80.00% in the control group, the difference was not statistieally sighifieant（P〉0.05）. The total effective rate of TCM syndromes in the observation group was 90.00%, which was higher than the total effective rate of the control group（66.67%） （P〈 0.05）. After treatment, the carotid intima-media thickness, mALb, β2-MG level and 24h, daytime and nighttime systolic blood pressure variation coefficient（SBPV） and diastolic blood pressure variation coefficient （DBPV） were lower than those of the control group（P〈0.05）. No significant adverse reactions were observed after treatment in both groups. Conclusion Dioseorea opposita cream combined with western medicine is effective in treating elderly hypertensive patients, which can significantly reduce carotid intima-media thickness, reduce urinary protein exudation, and improve blood pressure variation coefficient, which is safe.
作者
黄金龙
黄修解
康善平
HUANG Jinlong;HUANG Xiujie;KANG Shanping(Department of Geriatrics,Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning 530000,China;Second Department of Cardiology,Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning 530000,China)
出处
《中国现代医生》
2018年第28期4-7,共4页
China Modern Doctor
基金
广西中医药民族医药自筹经费科研课题(GZZC15-80)
关键词
老年
高血压
血压变异性
薯蓣膏
尿微量白蛋白
Β2微球蛋白
Elderly
Hypertension
Blood pressure variability
Dioseorea opposita cream
Urinary mieroalbumin
β2 mieroglobulin
