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活化白细胞黏附分子与肿瘤 被引量：4

Active Leukocyte Cell Adhesion Molecule and Tumors
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摘要 活化白细胞黏附分子(ALCAM)是免疫球蛋白基因超家族成员,主要表达在白细胞和胸腺上皮细胞,其通过异嗜性黏附形式(ALCAM-CD6)和同嗜性黏附形式(ALCAM-ALCAM)介导细胞间黏附。研究表明,ALCAM参与多种肿瘤的发生发展,与恶性黑色素瘤、结肠癌、乳腺癌和神经胶质瘤等侵袭与转移密切相关。 Activated leukocyte cell adhesion molecule （ ALCAM） is a member of immunoglobulin gene super family.It is mainly ex-pressed on leucocytes and thymic epithelial cells.ALCAM mediates cell -cell interactions by both heterophilic （ ALCAM-CD6 ） and ho-mophilic（ALCAM-ALCAM）.Studies show that ALCAM plays a role on tumorigenesis and progression.ALCAM expression is closely correlated with invasion and metastasis of several human tumors , including malignant melanoma ,colon carcinoma , breast cancer and glio-blastoma.
作者 钟立 张秉强
机构地区 重庆医科大学第一附属医院
出处 《黑龙江医学》 2014年第7期745-747,共3页 Heilongjiang Medical Journal
关键词 活化白细胞黏附分子 肿瘤 Activated- leukocyte cell adhesion molecule Tumor
分类号 R730.23 [医药卫生—肿瘤]
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同被引文献41

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黑龙江医学
2014年 第7期

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