摘要
目的研究石菖蒲(Acorus tatarinowii Schott)根茎部分的化学成分。方法利用包括MCI、硅胶、Sephadex LH-20、高效液相等色谱方法,对石菖蒲的根茎部分体积分数70%乙醇提取物进行系统的分离纯化,并结合理化常数与波谱技术进行结构鉴定。结果共分离鉴定12个化合物,分别为(7S,8R)-4,9'-dihydroxyl-3,3'-dimethoxyl-7,8-dihydrobenzofuran-1'-propylneolignan(1),(-)-南烛木树脂酚(2),dihydrocubebin(3),evofolin B(4),(+)-淫羊藿醇A2(5),β-谷甾醇(6),(+)-13-hydroxyspathulenol(7),aromadendrane-4β,10β-diol(8),anomallenodiol(9),(9CI)-cis-4-(3,4-dihydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butanone(10),(3E)-rel-4-[(3R,4S)-3,4-dihydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl]-3-buten-2-one(11)和ixerol B(12)。结论化合物2~4和7~12为首次从该属植物中分离得到,化合物5为首次从该植物中分离得到。
OBJECTIVE To study the chemical constituents from the stems of Acorus tatarinowii Schott.METHODS The chemical constituents were isolated from the 70% ethanol-soluble extract of the stems of Acorus tatarinowii Schott and purified by a series of column chromatography methods,including MCI,silica gel,Sephadex LH-20,HPLC and so on,and their structures were identified by physical chemical constants and NMR techniques.RESULTS A total of twelve compounds were isolated and identified as（7S,8R）-4,9′-dihydroxyl-3,3′-dimethoxyl-7,8-dihydrobenzofuran-1′-propylneolignan（1）,（-）-lyoniresinol（2）,dihydrocubebin（3）,evofolin B（4）,（＋）-icariol A2（5）,β-sitosterol（6）,（＋）-13-hydroxyspathulenol（7）,aromadendrane-4β,10β-diol（8）,anomallenodiol（9）,（9CI）-cis-4-（3,4-dihydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl）-2-butanone（10）,（3E）-rel-4-[（3R,4S）-3,4-dihydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl]-3-buten-2-one（11）,and ixerol B（12）,respectively.CONCLUSION Compounds 2-4 and 7-12 are isolated from the genus Acorus for the first time,and compound 5 is isolated from this plant for the first time.
作者
赵松峰
张晓
师秀琴
张晓坚
ZHAO Song-feng;ZHANG Xiao;SHI Xiu-qin;ZHANG Xiao-jian(Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Chin)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2018年第8期585-588,共4页
Chinese Pharmaceutical Journal
基金
河南省科技厅科技攻关项目资助(172102310430)
