摘要
目的:研究石菖蒲多糖的抗惊厥活性。方法:采用水对石菖蒲进行提取,分别用80%乙醇和90%乙醇对石菖蒲水提取液进行2次醇沉,制备石菖蒲多糖;然后采用戊四唑(PTZ)制造小鼠惊厥模型,并对石菖蒲多糖经不同给药途径给药时的抗惊厥活性或辅助治疗作用进行考察。结果:腹腔注射石菖蒲多糖一次给药时,对小鼠惊厥无明显影响;灌胃给药连续7d后,石菖蒲多糖在4g/kg和8g/kg时均显著延长惊厥小鼠的死亡时间,且能降低小鼠的死亡率。结论:石菖蒲多糖没有直接的抗惊厥作用,但却可以起到重要的辅助作用。
Objective： To study the anticonvulsant acivity of polysaccharides in Acorus tatarinowii. Methods：Acorus tatarinowii was extracted by water,and was deposited with 80% and 90% EtOH respectively,which is to obtain the polysaccharides contained. And the anticonvulsant activity of the polysaccharides was observed in mice with PTZ-induced seizures. Results： Polysaccharides in Acorus tatarinowii showed no effect on mice with seizures, when administered intraperitoneally once. But after administered ig for 7days, Polysaccharides in Acorus tatarinowii prolonged remarkably the dying-time of mice with PTZ-induced seizures and reduced mortality at 4 g/kg and 8 g/kg. Conclusion： Polysaccharides in Acorus tatarinowii have no anticonvulsant activity, but they have an important role in anticonvulsant procedure.
出处
《中国医药导报》
CAS
2009年第26期39-40,共2页
China Medical Herald
关键词
石菖蒲
多糖
抗惊厥
Acorus tatarinowii
Polysaccharides
Anticonvulsant
