摘要
目的 检测类风湿关节炎(RA)患者外周血中白细胞介素-6(IL-6)、TNF-α、CRP水平,分析其水平与RA疾病的相关性,探讨IL-6对RA患者病情的意义。方法根据2009年ACR/EULAR制定类风湿关节炎诊断标准,收集初治RA患者(试验组)以及同期健康体检者(对照组)的血液标本,采用双抗夹心ELISA法检测患者的IL-6、TNF-α,并测定类风湿因子(RF)、抗CCP抗体、CRP、WBC、PLT、HDL-C、LDL-C水平。结果试验组患者IL-6、TNF-α、CRP、WBC、PLT、RF、抗CCP抗体、LDL-C检测指标均显著高于健康对照组,HDL-C低于健康对照组(P<0.05);在试验组中,血清IL-6水平与TNF-α、CRP、DAS28-CRP、RF、抗CCP抗体水平均呈正相关(P<0.05)。结论RA患者中IL-6水平明显升高,检测RA患者血清中IL-6水平变化,有助于类风湿关节炎的病情变化评估。
Objective To detect the serum interleukin -6 （IL-6）, TNF-α （tumor necrosis factor-α） and CRP （C-reac tive protein） levels in patients with rheumatoid arthritis （RA） and analyze the correlation between the levels and RA disease activity,in order to investigate clinical significance of IL-6 in patients with RA. Methods According to the di- aghositic criteria of RA made by ACR/EULAR in 2009 year, patients with RA（experimental group） and healthy controls （control group） were collected to measure the IL-61 TNF-α levels by ELISA and the levels of RF,anti-CCP antibody, CRP, WBC, PLT, HDL-C, LDL-C. Results The serum IL-6, TNF-α, CRP, WBC, PLT, RF, anti-CCP, LDL-C levels in RA patients in experimental group were higher than those in the control group, and HDL-C was lower than that in control group（P〈0.05）. In the experimental group, the serum IL-6 levels were positively correlated with the levels of TNF-α, CRP, DAS28-CRP, RF, and anti-CCP antibody（P〈0.05）. Conclusion The level of IL-6 in RA patients is significantly increased, and to detect the changes of IL-6 level in serum of RA patients, which is helpful to the evalu- ation of the illness change of rheumatoid arthritis.
作者
向惠
陈海娟
XIANG Hui CHEN Haijuan(Department of Rheumatology, the People＇s Hospital of Changji I-Iui Autonomous Prefecture in Xinjiang Uygur Au- tonomous Region, Changji 831100, China)
出处
《中国现代医生》
2017年第4期13-15,共3页
China Modern Doctor
关键词
类风湿关节炎
IL-6
自身免疫病
TNF-Α
Rheumatoid arthritis
Interleukin-6
Autoimmune disease
tumor necrosis factor-α
