摘要
目的检测类风湿性关节炎(RA)患者C1q、血清淀粉样蛋白-A(SAA)和白细胞介素-6(IL-6)水平,分析其水平与RA疾病活动的相关性,探讨C1q、SAA及IL-6在RA血清中的变化及意义。方法收集临床确诊的RA患者血清100例,活动期和缓解期患者各50例,以30例健康体检者作为对照组。采用免疫透射比浊法测定C1q的水平,采用ELISA法测定SAA的水平,采用电化学发光法测定IL-6的水平。结果RA患者活动组C1q水平高于缓解组和正常对照组,缓解组C1q水平高于正常对照组(P<0.05),RA患者活动组SAA和IL-6水平高于缓解组和正常对照组(P<0.05),RA患者缓解组SAA和IL-6水平与正常对照组相比无统计学意义(P>0.05)。结论 RA患者C1q、SAA及IL-6水平的变化对RA病情活动性和疗效的判断有一定的临床意义。
Objective To detect the serum Clq, serum amyloid A protein（SAA） and interleukin -6（IL -6） lev- els in patients with rheumatoid arthritis （RA） and analyze the correlation between the levels and RA disease activity, in order to investigate clinical significance of changes of the three index in patients with RA. Methods Fifty pa- tients with active RA , 50 patients with remissive RA and 30 healthy controls were collected to measure the C1 q lev- el by ITA, SAA by ELISA and IL -6 by ECL. Results The serum C1 q level from high to low were active RA pa- tients, remissive RA patients and the normal control group, （ P 〈 0.05 ）. The serum SAA and IL - 6 levels in active RA patients were higher than those in remissive RA patients and the normal control group （ P 〈 0.05 ）, there was no statistical difference between the remissive RA patients and the normal control group in the serum SAA and IL -6 levels （ P 〉 0.05 ）. Conclusion The changes of serum C 1 q, SAA and IL - 6 levels in patients with RA have cer- tain clinical significance for the judgment of disease activity and curative effect in rheumatoid arthritis.
出处
《中国卫生检验杂志》
北大核心
2013年第10期2311-2313,共3页
Chinese Journal of Health Laboratory Technology
基金
河南省科技厅科技攻关项目(0624410092)
