摘要
目的探讨血清前白蛋白评估重症社区获得性肺炎（SCAP）患者预后的临床价值。方法回顾性分析2010年8月至2014年8月西安医学院第一附属医院收治的87例SCAP患者的临床资料，按预后分为治愈组（64例）、死亡组（23例），检测两组患者入院第1天，第5天及观察终点（出院或死亡前最后一次，平均（19．2±5．7）天）血清前白蛋白含量，用统计软件SPSS19．0进行数据分析，定性资料采用χ^2检验，计量资料两两比较采用独立样本t检验，组内不同时间点数据比较采用重复测定方差分析。结果血清前白蛋白在治愈组和死亡组入院第1天比较差异无统计学意义（P〉0．05），第5天及观察终点比较差异具有统计学意义（P〈0．01）。并且治愈组血清前白蛋白在第1天，第5天和观察终点逐渐升高，而死亡组血清前白蛋白逐渐下降，同一组不同时间点数据两两比较差异具有统计学意义（P〈0．01）。结论血清前白蛋白持续低水平提示病情危重，预后不佳。动态观察血清前白蛋白水平对判断SCAP预后有一定的评估价值。
Objective To investigate the prognostic value of serum prealbumin level in patients with severe community-acquired pneumonia （SCAP）. Methods The clinical data of 87 patients with SCAP were retrospectively analyzed, who were admitted to the Department of Respiratory and Critical Care Medicine of the First Affiliated Hospital of Xi＇an Medical University from August 2010 to August 2014. They were divided into the survival group （64 cases） and the death group （23 patients）. Serum prealbumin was measured at Day 1 and 5, and the clinical endpoint （the final measurement before hospital discharge or death, mean （19.2 ± 5.7 ） days）. The clinical data were analyzed by spss statistics version 19.0. The qualitative data were analyzed by χ^2 test, t test of independent samples between the two groups, and repeated analysis of variance in each group. Results There was no significant difference in serum prealbumin on Day 1 between the two groups （P 〉 0. 05）. On Day 5 and at the clinical endpoint, it showed significant difference （P 〈 0.01 ）. The level of serum prealbumin increased progressively from Day 1 to the clinical endpoint in the survival group, but it decreased in the death group （P 〈 0. 01 ）. Conclusion The low level of serum prealbumin indicates poor outcome for patients with SCAP. Dynamic observation of serum prealbumin level has prognostic value in predicting the outcome of SCAP.
出处
《临床肺科杂志》
2016年第3期418-421,共4页
Journal of Clinical Pulmonary Medicine
关键词
前白蛋白
重症社区获得性肺炎
预后
serum prealbumin
severe community -acquired pneumonia
prognosis
