摘要
目的:探讨卵巢高分化黏液性癌(highly differentiated Ovarian mucinous carcinoma,HDOMC)患者中MMP-2、MMP-9、S100A14的表达水平及意义。方法:采用免疫组化法对40例正常卵巢组织、43例卵巢黏液性肿瘤(Ovarian mucinous tumor,OMT)、80例HDOMC患者中MMP-2、MMP-9、S100A14的表达水平进行检测,并分析HDOMC患者中S100A14表达与MMP-2、MMP-9表达的相关性。结果:MMP-2、MMP-9、S100A14在正常卵巢组织、OMT、HDOMC患者中的表达水平呈递增趋势,且两两组间比较差异显著(P<0.05)。Spearman相关分析:HDOMC患者中S100A14表达与MMP-2、MMP-9表达水平两两呈正相关(P<0.05)。MMP-2、MMP-9、S100A14表达水平与HDOMC患者手术-病理分期(FIGO)、CA-125水平有关(P<0.05);与年龄、肿瘤直径、淋巴结转移无关(P>0.05)。结论:MMP-2、MMP-9、S100A14表达水平升高与HDOMC发生、进展、早期转移具有显著相关性,早期联合筛查这些指标对HDOMC病情演变及治疗预后评估具有重要价值。
Objectives： To investigate the expression levels of MMP- 9,S100A14 and MMP- 2 in patients with highly differentiated ovarian cancer and its significance. Methods： Immunohistochemistry was used to detect the expression of S100A14 and MMP- 2,MMP- 9 in 40 cases of normal ovarian tissues,43 cases of mucinous tumor（ OMT） and 80 HDOMC patients,to analyze the correlation between S100A14 expression and MMP- 2,MMP- 9 expression in HDOMC patients. Results： The expression of MMP- 2,MMP- 9,S100A14 in the normal ovarian tissues,OMT and HDOMC were increased,with significant difference between the groups（ P 〈0. 05）. According to spearman correlation analysis,the level of S100A14 in HDOMC patients was positively correlated with the level of MMP- 2 and MMP- 9（ P 〈0. 05）. MMP- 2,MMP- 9,S100A14 expression levels were associated with HDOMC（ FIGO） and Ca- 125 levels（ P 〈0. 05）,without association with age,tumor size and lymph node metastasis（ P 〉0. 05）. Conclusion： Increase in MMP- 2,MMP- 9 and S100A14 expression levels is significantly correlated with the occurrence,progression and early metastasis of HDOMC,and early combined screening of these indexes has important value in the development of HDOMC disease and the evaluation of prognosis.
出处
《中国性科学》
2016年第10期26-28,共3页
Chinese Journal of Human Sexuality
关键词
黏液性癌
表达水平
联合筛查
病理分期
相关性
Mucinous carcinoma
Expression level
Combined screening
Pathological staging
Correlation
