摘要
目的观察CD10在卵巢黏液性囊腺瘤(Mucinous adenoma,MA)、黏液性交界性肿瘤(Mucinous borderline tumor,MB)和黏液性腺癌(Mucinous adenocarcinoma,MC)间质细胞中的表达,探讨CD10在卵巢黏液性肿瘤(Ovarian mucinous tumor,OMT)恶性进展中的作用及意义。方法选用明确诊断的OMT标本156例,其中包括42例MA、72例MB和42例MC,同时选取20例正常卵巢组织标本。应用免疫组织化学方法对其进行CD10抗体标记并分析其表达情况。结果 CD10在20例正常卵巢组织中呈阴性表达;CD10在42例MA中,28例阴性,14例阳性;72例MB中,18例阴性,54例阳性;42例MC间质中,全部呈阳性。CD10在MA-MB-MC间质细胞中阳性表达率逐渐升高(33.3%、75%、100%,P<0.0001)。结论 CD10在卵巢黏液性肿瘤间质的高表达与肿瘤进展密切相关。
Objective To evaluate the expression of CD10 in stromal cells of mucinous adenoma,mucinous borderline tumor and mucinous adenocarcinoma and examine their role in tumor progression.Methods Immunohistochemical study for CD10 was performed on 20 cases of normal ovarian tissue,42 cases of mucinous adenoma（MA）,72 cases of mucinous borderline tumor（MB）and 42 cases of mucinous adenocarcino-ma（MC）.Results In 20 cases of normal ovarian tissue,CD10 was not detected in any stromal cell.In 42 cases of MA stroma,the expression of CD10 was negative in 28,positive in 14;in 72 cases of MB stroma,the corresponding parts were 18 and 54,whereas in MC stroma,the corresponding parts were 0 and 42.The proportion of CD10-positive cells increased from MA to MC（33.3%,75%,100%,P〈0.0001）.Conclusion CD10 overexpressions in stromal cells may play an important role in the development of ovarian mucinous tumor.
出处
《实用肿瘤学杂志》
CAS
2016年第3期235-239,共5页
Practical Oncology Journal
