摘要
目的:研究高效抗逆转录病毒疗法(HAART)治疗HIV感染和艾滋病(AIDS)患者的治疗效果和HAART治疗后患者的生存时间。方法:收集3 100例HIV感染和AIDS患者接受HAART治疗12个月,每月用流式细胞仪Multi SET绝对计数法检测患者CD4+T细胞水平,b DNA法(检测范围1.60 log^6.10 log RNA拷贝/m L)检测血浆HIV-1病毒载量1次,并对患者进行严密的临床观察。结果:治疗后12个月CD4+T细胞计数平均升高430×106/L(P<0.01)。病毒载量于治疗后8个月全部降至可测水平(1.70 log拷贝/m L)以下,平均下降45 log拷贝/m L。结论:艾滋病患者经HAART治疗后有极为显著的效果,且经过治疗之后,患者的生存率与相关文献比较有很大的提高。
Objective To study the treatment of highly active antiretroviral therapy （HAART） in patients with HIV infection and AIDS and the patients＇ survival time after HAART treatment. Methods Three thousand and one hundred cases of HIV infection and AIDS patients received HAART in 12 months by monthly flow cytometry instrument MultiSET absolute counting method detecting the CD4＋ T cell levels, bDNA method （detection range 1.60 log - 6.10 log RNA copies/mL） detecting serum HIV-1 viral load under rigorous clinical observation. Results Twelve months after treatment, the CD4＋ T cell count increased an average of 430× 10^6/L （P 〈 0.01）. Eight months after treatment, all viral loads reached their measurable levels （below 1.70 log copies/mL） by decreasing 45 log copies/mL on average. Conclusion H1V/AIDS patients showed treatment extremely significant possitive responses to highly active antiretroviral therapy. The patients＇ survival rate after treatment has greatly improved compare to that in previous literature.
出处
《实用医学杂志》
CAS
北大核心
2015年第17期2826-2829,共4页
The Journal of Practical Medicine
基金
广西贵港市科学研究与技术开发计划项目(编号:贵科学攻关1209028)
