摘要
目的 :探讨口腔念珠菌病、单纯疱疹性口炎与HIV患者免疫状况的关系。方法 :选取2013年1月~2015年12月血清HIV-1感染阳性者126例,其中合并口腔念珠菌病患者67例,合并单纯疱疹性口炎患者29例,无口腔念珠菌病/单纯疱疹性口炎患者30例,检测患者外周血CD4+T淋巴细胞计数、IL-4、IL-17(A/F)、IFN-γ等。结果 :合并口腔念珠菌病HIV患者CD4+T细胞计数和IL-17(A/F)分别为76(199.00)mm3和19.08(14.15)pg/m L,低于其他患者,而病毒载量为160772(401525.00)VLcopies/m L,高于其他患者,差异比较有统计学意义;合并单纯疱疹性口炎HIV患者与无口腔念珠菌病/单纯疱疹性口炎HIV患者外周血相关检测因子比较差异无统计学意义;Logistic回归模型显示HIV患者口腔念珠菌病发生与IL-17(A/F)有关,IL-17(A/F)为罹患口腔念珠菌的保护因素。结论 :合并口腔念珠菌病HIV患者CD4+T细胞计数和IL-17(A/F)水平低,病毒载量高,其中IL(A/F)发挥重要作用;合并单纯疱疹性口炎HIV患者暂未查见有意义指标。
Objective To investigate oral candidiasis, herpes simplex stomatitis and HIV patients immune status correlation. Methods Selected from January 2013 to December 2015, 126 patients with serum HIV-1 infection positive, wherein the combined oral candidiasis in patients with 67 cases, combined herpes simplex stomatitis 29 patients, without oral candidiasis/herpes simplex stomatitis 30 patients, detected peripheral blood CD4+T lymphocyte count, IL-4, IL-17(A/F), IFN-γ etc. Results Combined oral candidiasis HIV patients CD4 + T cell count and IL-17(A/F)were 76(199.00)mm3 and 19.08(14.15)pg/ml, lower than other patients, viral load was 160772(401525.00)VLcopies/ml, higher than other patients, the difference was statistically significant; combined herpes simplex stomatitis HIV patients and without oral candidiasis/herpes simplex stomatitis HIV patients peripheral blood related factors difference had no statistically significant; Logistic regression model showed that HIV patients with oral candidiasis and IL-17(A/F)related), IL-17(A/F)protection factors of oral candidiasis. Conclusion The combined oral candidiasis HIV patients CD4 + T cell count and IL-17(A/F)low level, high viral load, whereas IL(A/F)play an important role; The combined herpes simplex stomatitis HIV patients yet found meaningful indicators.
出处
《湖南师范大学学报(医学版)》
2016年第4期62-64,65,共4页
Journal of Hunan Normal University(Medical Sciences)