摘要
目的基于药物体系的发现,并运用药物体系质量评价模式全面表征石菖蒲质量并关联分析,评价石菖蒲质量。方法采用高效液相色谱法同时测定石菖蒲中原儿茶酸、香草酸、2,4,5-三甲氧基苯甲酸、β-细辛醚、α-细辛醚等5种有效指标性成分的含量。结果基于药物体系质量评价模式对石菖蒲进行有效指标性成分含量及其相对比值的质量表征,并关联分析,使用非关联系数δ、非关联度、关联度等相关概念指标反映与基准饮片样品15质量的关联性。结果表明,样品1、6、9、12、14中有效指标性成分含量总体高于样品15,样品7中有效指标性成分含量与样品15接近。以样品15为基准计算各样品与样品15的非关联系数δ样品7、1、10与样品15质量关联度较高。综合质量表征及关联分析结果,样品1、7饮片质量优良度居前,其次为样品12、14、9、6。结论基于药物体系质量评价模式对石菖蒲质量进行关联分析研究,以具有确切药效的饮片为基准,结合关联度分析,可综合精准地评价出石菖蒲质量优次。
Objective To establish quality representation and correlation analysis method of Shichangpu（ Acorus tatarinowii Schott） based on a new model for quality evaluation of drug system. Methods Use HPLC method for simultaneous determination of 5 effective index components in fifteen numbers of Shichangpu（ Acorus tatarinowii Schott） , including Protocatechuate, Vanillic acid, 2,4,5-Trimethoxy-benzoic acid,β-asarone, and α-asarone, then analysis these data correlatively. Results To characterize quality based on the content and the content relative ratio of effective index components and analysis associ-ated. Using non-correlation coefficient δ, non-correlation, correlation to reflect the quality relevance of pieces. The result shows the total content of effective index components in No. 1, No. 6, No. 9, No. 12, No. 14 is higher than No. 15 and No. 7 is closer to No. 15. Using No. 15（its therapeutic effect has been identified） as the reference to get the difference between these relative ratio of effective index components, and its sum of absolute value of these difference represent non-correlation coefficientδ. Namely,compared with No. 15,the correlation degree of quality representation of No. 1,No. 7 and No. 10 is higher. Consoli-dated quality characterization and correlation analysis, the quality of No. 1 and No. 7 are excellent, No. 7、No. 12、No. 14、No. 9 and No. 6 followed. Conclusion Quality representation and correlation analysis of Shichangpu（ Acorus tatarinowii Schott） are based on a new quality evaluation model of drug system. Considering quality representation based on the content and the content relative ratio of effective index components comprehensively, using No. 15 as the reference. This paper reports the specific applications of new way of thinking model for the quality representation and evaluation of Shichangpu（ Acorus tatarinowii Schott） .
出处
《环球中医药》
CAS
2015年第3期274-280,共7页
Global Traditional Chinese Medicine
基金
国家"十二五"科技支撑计划(2012BAI29B06)
北京中医药大学科研创新团队资助项目(2011-CXTD-12)
北京中医药大学重点学科开放课题(2013-2DXKKF-23)
关键词
石菖蒲
质量评价
关联分析
原儿茶酸
香草酸
2
4
5-三甲氧基苯甲酸
Β-细辛醚
Α-细辛醚
Shichangpu（Acorus tatarinowii Schott）
Quality evaluation
Correlation analysis
Protocatechuate
vanillic acid
2,4,5-Trimethoxybenzoic acid
β-asarone
α-asarone
