摘要
目的确定醒脑滴丸血清药物化学。方法建立醒脑滴丸及其大鼠体内血清HPLC指纹图谱分析方法,比较醒脑滴丸给药及未给药大鼠血清的HPLC指纹图谱,通过添加对照品的方法对指纹峰进行确认。结果醒脑滴丸给药后,5个成分未被吸收或已被代谢,血中出现了18个移行成分,其中10个为原型成分,8个为代谢成分。结论初步确定醒脑滴丸血清药物化学,为进一步阐明醒脑滴丸的药理活性物质基础及其作用机理奠定了基础。
Objective To confirm the serum pharmacochemistry of Xingnao Cutta Pills. Methods Analysis method of HPLC fingerprint for Xingnao Gutta Pills and rat serum with Xingnao Gutta Pills was established. HPLC fingerprints of Xingnao Gutta Pills and rat serum with or without Xingnao Gutta Pills were compared and the fingerprint peaks were confirmed by addition of control article. Results In serum with Xingnao Gutta Pills, 5 compounds were not absorbed or had been metabolized. 18 compounds were detected, 10 of them were original compounds, 8 of them were metabolits. Conclusion Serum pharmacochemistry of Xingnao Gutta Pills is confirmed initially, which establishes a basis for further study on active compound in Xingnao Gutta Pills and mechanism.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2006年第9期621-622,626,共3页
Journal of Beijing University of Traditional Chinese Medicine
