摘要
目的从文献计量学角度对国内外利奈唑胺PK/PD的相关文献进行分析,为抗感染研究提供参考。方法检索截止时间2014年2月为止,检索Embase、Pubmed、SCI和中国知网数据库中利奈唑胺PK/PD相关文献。利用End Note X7软件进行分类整理,对纳入文献的发表年份、期刊、作者、研究机构、被引频次、文章类型、国家、研究内容等进行计量分析。结果检索文献共494篇,符合要求301篇,其中外文287篇,中文14篇。外文第一篇文献发表于1998年,此后逐渐增长;发文量最多期刊Antimicrobial Agents and Chemotherapy;文章类型主要是基础研究(146篇),临床研究相对较少(33篇);研究内容包括PK/PD研究意义、利奈唑胺PK/PD特点、根据PK/PD指导利奈唑胺临床合理用药等。结论国内外对利奈唑胺PK/PD关注逐渐增多,但国内文章较国外文章在数量、水平上均有很大差距;利奈唑胺PK/PD相关参数指导个体化给药临床相关研究逐渐增多并深入。
Objective To investigate the pharmacokinetics/pharmacodynamics（PK/PD） on linezolid based on a bibiometric analysis and provide reference for anti-infection. Methods We searched Pub Med, SCI, Embase and CNKI until 2014. The year, journal, author, research institutions, citation frequency, type of literature, nation and contents were analyzed. Results A total of 301 out of the retrieved 494 papers with 287 English papers and 14 Chinese papers were included. The first English paper was published in 1998 and the number of published papers tended to increase. The journal with maximum number of papers was Antimicrobial Agents and Chemotherapy. The main publication type was basic research（146）, and clinical research（33）. The meaning and character of linezolid PK/PD were analyzed. Conclusion More oversea researchers pay attention to linezolid PK/PD study. The research level of English papers is higher than that of Chinese and focuses more on individual administration.
出处
《中南药学》
CAS
2015年第1期102-105,共4页
Central South Pharmacy
基金
海南省社会发展基金(编号:SF201340)
