摘要
目的分析棘白菌素类药物对真菌生物被膜作用的相关文献,了解其研究现状。方法在中外文献数据库(Em Base,Pub Med,SCI,CNKI及Sino Med)检索2001年至2013年相关文献,用End Note X7软件进行分类整理,对纳入文献的发表年份、文献类型、国家、第一作者、期刊、被引频次及研究内容等进行计量分析。结果共纳入外文148篇,中文5篇,以论著为主。文献最高被引157次,研究最多的菌株是白色念珠菌,共62篇;棘白菌素类单用对念珠菌生物被膜研究最多,且以卡泊芬净对白色念珠菌研究最为深入,共24篇;棘白菌素联合用药研究共14篇,临床研究相对较少(3篇)。结论棘白菌素单用对真菌生物被膜有很好的抑制作用,尚未发现理想的联合治疗方案,未来研究重点是生物被膜相关体内感染模型和研究从基础向临床转化。
Objective To investigate the development of echinocandin research on fungal biofilm from international and domestic databases from2001 to 2013. Methods All publications were searched on international and domestic databases（ SCI,Pub Med,Em Base,CNKI and Sino Med）and were screened by Endnote X7 software,then analysis was performed according to the publication year, author, article types, literature source,times cited and research content. Results A total of 153 publications（ most were research articles） including 148 international and 5domestic papers were searched from databases. The highest citation frequency of the literature was 157 times. A total of 62 research articles focused on Candida albicans. Most were monotherapy of echinocandin for fugal biofilm. A total of 24 research articles focused on caspofungin affecting the biofilm of C. Albicans. Fourteen papers concentrated on echinocandin combinations and few papers involved clinical research（ three papers）. Conclusion The monotherapy of echinocandin can inhibit fugal biofilm,but combinations were not ideal. Biofilm infection model in vivo is still one of the key research areas,as well as the transition from basic research to clinical research.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第4期300-303,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家科技部十二五重大专项滚动课题基金资助项目(2012ZX09303004-002)
关键词
棘白菌素
生物被膜
文献研究
计量分析
真菌
echinocandin
biofilm
bibliographic study
bibliometric analysis
fugus
