摘要
轻度认知障碍(mild cognitive impairment,MCI)群体较同龄对照群体有着更高的阿尔茨海默病(Alzheimer's disease,AD)转化风险。然而迄今尚无证据显示有任何药物治疗能够改善MCI,因此有必要将目光转向认知干预。本文基于Clare和Woods对认知干预的分类,综述了以往在认知刺激、认知训练以及认知康复三个方面所进行的研究,以期厘清这些干预措施对改善MCI个体认知功能的效果。结果表明:认知干预在多项认知域,包括记忆、执行功能、加工速度、注意力和社会功能,均表现出一定效果,但其机制并未明确。未来的认知干预研究一方面应加强对MCI病因及症状异质性的控制并借助认知神经科学的技术手段来探索认知干预的神经机制,另一方面应尝试融合认知刺激、认知训练和认知康复三种干预方式以期提升干预的临床效果。
Compared with age-matched controls, mild cognitive impairment (MCI) populations are at a higher risk of developing Alzheimer's disease(AD). There is no consensus that any pharmacological treatment can improve MCI, thus it is plausible to turn attention to cognitive interventions. This paper reviewed the prior researches on cognitive stimulation, cognitive training, and cognitive rehabilitation for MCI based on the categories defined by Clare and Woods in order to clarify the effect of these interventions on improving cognitive function in MCI individuals. The results indicate that cognitive interventions may improve multiple cognitive domains including memory performance, executive functions, processing speed, attention, and social functions in adults with MCI, while the mechanism remains unclear. It suggested that further studies should examine the mechanism of cognitive intervention by applying neuroscience technology and strengthening the control of heterogeneity of the etiologies and symptoms of MCI, and improve the clinical effect by combining cognitive stimulation, cognitive training, and cognitive rehabilitation.
作者
王晶
何昊
邱月虹
陈毅琦
张浩波
罗跃嘉
关青
Wang ring;He Hao;Qiu Yuehong;Chen Yiqi;Zhang Haobo;Luo Yuejia;Guan Qing(College of Psychology and Sociology,Shenzhen University,Shenzhen 518060,China;Key Laboratory of Emotion and Social Cognitive Science of Shenzhen City,Shenzhen 518060,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2019年第1期85-90,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金项目(31571129).
关键词
轻度认知障碍
认知干预
认知刺激
认知训练
认知康复
Mild cognitive impairment
Cognitive intervention
Cognitive stimulation
Cognitive training
Cognitive rehabilitation
