摘要
阿尔茨海默病(AD)是最常见的,与年龄相关的老年性痴呆症,其主要病理组织学标志是老年斑和神经元纤维缠结。糖原合成激酶-3β(GSK-3β)是糖原合成的限速酶,其功能失调会影响神经元的多种生理活动,尤其与老年斑和神经元纤维缠结形成密切相关。笔者总结了GSK-3β在AD发生和发展过程中所发挥的作用及GSK-3β抑制剂治疗AD的研究现状。
Alzheimer disease (AD) is the most common age-related senile dementia. Senile plaques and neurofibrillary tangles are two histopathological hallmarks of this disease. Glycogen synthase kinase-3β(GSK-3β) is a key enzyme in glycogen synthesis. The dysregulation of this kinase contributes to many disorders in neurophysiology, especially the formation of senile plaques and neurofibrillary tangles. In this review, we conclude the effects of GSK-3β on the development of AD and the current studies of GSK-3β inhibitors in the treatment of AD.
作者
张梦阳
王玥
Zhang Mengyang;Wang Yue(Clinical College, Capital Medical University, Beijing 100069, China;Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China)
出处
《中华诊断学电子杂志》
2019年第2期98-102,共5页
Chinese Journal of Diagnostics(Electronic Edition)
基金
首都医科大学附属北京朝阳医院"科技新星"项目
