摘要
目的探讨老年轻度认知障碍(mild cognitive impairment,MCI)患者的社会支持水平对认知功能、抑郁情绪的影响。方法于2018年3月至9月,选取阳谷县闫楼镇52个村庄60岁以上的受试者5765名,应用简易精神状态检查(mini-mental state examination,MMSE)、日常生活活动能力量表(activities of daily living,ADL)进行筛查并回收有效问卷4750份。根据《精神障碍诊断和统计手册》第4版(DSM-Ⅳ)作为临床诊断标准,诊断出MCI患者733例(患者组),认知功能正常者3662人(健康对照组)。采用社会支持评定量表(social support rating scale,SSRS)、简版老年抑郁量表(geriatric depression scale-15,GDS-15)进行评定。应用SPSS 26.0统计软件进行独立样本t检验,卡方检验,Pearson相关分析和多元线性回归分析。结果MCI患者社会支持在各维度得分[社会支持总分(48.55±9.72)分,客观社会支持(16.49±4.00)分,主观社会支持(24.28±4.75)分,社会支持利用(7.78±2.85)分]均显著低于健康对照组[社会支持总分(50.94±7.66)分,客观社会支持(17.23±3.42)分;主观社会支持(25.59±3.61)分,社会支持利用(8.13±2.71)分],差异有统计学意义(t=-6.291,-4.363,-8.245,-3.068,均P<0.05)。MCI患者社会支持各维度(总分、客观支持、主观支持、支持利用度)与认知功能均呈显著正相关(r=0.084、0.062、0.128、0.011,均P<0.05),社会支持各维度和抑郁得分均呈显著负相关(r=-0.240、-0.195、-0.200、-0.169,均P<0.01)。主观社会支持、客观社会支持和社会支持利用度能够正向预测MCI患者的MMSE评分(β=0.190,0.007,0.029,均P<0.05),能够负向预测MCI患者的GDS-15评分(β=-0.145,-0.098,-0.105,均P<0.05)。结论良好的社会支持是MCI患者认知功能和抑郁的保护因素。
Objective To explore the impact of social support on cognitive function and depression in patients with mild cognitive impairment(MCI).Methods From March to September 2018,5765 subjects over 60 years old from 52 villages in Yanlou Town,Yanggu County were selected and they were screened by mini-mental state examination(MMSE)and activities of daily living(ADL).Finally 4750 valid questionnaires were recovered.According to the"Diagnostic and Statistical Manual of Mental Disorders"4th Edition(DSM-Ⅳ),733 patients with MCI(patient group)and 3662 patients with normal cognitive function(healthy control group)were diagnosed.The social support rating scale(SSRS)and geriatric depression scale-15(GDS-15)were used to evaluate the patients.SPSS 26.0 software was used for independent sample t-test,chi-square test,Pearson correlation analysis and linear regression analysis.Results The total score of social support(48.55±9.72),objective social support(16.49±4.00),subjective social support(24.28±4.75)and social support utilization(7.78±2.85)in patients group were significantly lower than those in the healthy control group(total score of social support(50.94±7.66),objective social support(17.23±3.42),subjective social support(25.59±3.61)and social support utilization(8.13±2.71)).The differences were statistically significant(t=-6.291,-4.363,-8.245,-3.068,all P<0.05).All the dimensions of social support(total score,objective support,subjective support,support utilization)were positively correlated with cognitive function(r=0.084,0.062,0.128,0.011,all P<0.05),and negatively correlated with depression score(r=-0.240,-0.195,-0.200,-0.169,all P<0.01).Subjective social support,objective social support and social support utilization could positively predict MMSE score of MCI patients(β=0.190,0.007,0.029,all P<0.05),while could negatively predict the GDS-15 score of MCI patients(β=-0.145,-0.098,-0.105,all P<0.05).Conclusion Good social support is a protective factor for cognitive function and depression in MCI patients.
作者
宋振玉
王念芬
刘晓黎
王立云
孙丽
杜怡峰
Song Zhenyu;Wang Nianfen;Liu Xiaoli;Wang Liyun;Sun Li;Du Yifeng(Department of Neurology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2021年第6期522-527,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金项目(81861138008)。
