摘要
目的研究载脂蛋白E(ApoE)基因多态性与氟伐他汀降脂疗效的关系。方法运用等位基因特异性多重PCR技术,对93例采用氟伐他汀治疗的高脂血症患者ApoE基因进行分型,分析基因型与血脂水平及氟伐他汀降脂疗效的关系。结果不同ApoE基因型总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)差异有统计学意义(ε4/3>ε3/3>ε3/2,P<0.05);氟伐他汀治疗12周后(20 mg/d),ε3/2基因型个体较ε3/3基因型个体TC、LDL-C水平明显降低,差异有统计学意义(P<0.05)。结论 ApoE基因多态性与氟伐他汀降低TC、LDL-C的疗效相关。
Objective To explore the relationship of apolipoprotein E（ApoE）gene polymorphism with the lip id-lowering effect of fluvastatin. Methods The multi-AMRS PCR method was used to detect the ApoE gene polymorphism in 93 hyperlipemia patients treated with fluvastatin. The relation of ApoE gene polymorphism with the lip id levels and the lipid lowering effect of fluvastatln was analyzed. Results The TC and LDL-C levels in different gen otype subgroups had statistical differences （ε4/3〉ε3/3〉ε3/2,P〈0.05 ） ; After 12-week treatment with fluvastatin 20 mg/d,the cases with ε3/2 genotype had a significantly greater reduction in TC and LDL C levels compared to those with ε3/3 genotype （P〈0. 05）. Conclusion The ApoE polymorphism is associated with lowering TC and LDI. C levels by fluvastatin treatment.
出处
《检验医学与临床》
CAS
2011年第18期2181-2182,共2页
Laboratory Medicine and Clinic
基金
广东省深圳市科技计划资助项目(201003062)
关键词
载脂蛋白E类
降血脂药
氟伐他汀
多态现象
遗传
高脂血症
apolipoproteins E
antilipemic agents
fluvastatin
polymorphism, genetic
hyperlipi demias
