摘要
目的探讨新疆地区维吾尔族长寿老人载脂蛋白E基因多态性与血压的关系。方法以课题组1997—2003年多次流行病学调查所得维吾尔族长寿老人144例为研究对象,根据24 h动态血压测量结果将其分为正常组(107例)和高血压组(37例)。应用聚合酶链反应-限制性片段长度多态性方法检测两组人群的载脂蛋白E(Apo E)基因多态性。结果正常组与高血压组Apo E基因型分布间差异无统计学意义(P>0.05),两组中E3/3占的比例均较其他基因型高,分别为76.6%(82/107)、64.9%(24/37);两组Apo E等位基因分布间差异有统计学意义(P<0.05),高血压组中携带Apo Eε4频率(9.5%,7/37)高于正常组(2.3%,5/107)。不同Apo E表型的高血压患者的收缩压间差异有统计学意义(P<0.05),带有ε4等位基因的高血压患者收缩压比带有其他等位基因者高。结论Apo E基因多态性与新疆地区维吾尔族长寿老人收缩压相关。
[AbstraCt] ObjeCtive To study the relationship between apolipoprotein genotypes and blood pressure in longevous elderly Xinjiang Uighur people. Methods 144 longest Uighur elderly were recruited as the research subjects by several epidemiological investigations from 1997 to 2003 and divided into normotensive group（n = 107）and hypertension group（n =37）according to 24 _ hour ambulatory blood pressure monitoring results. Their apolipoprotein E（ApoE）genetic polymorphism was detected by polymerase chain reaction _ restriction fragment length polymorphism（ PCR _ RFLP）. Results The ApoE genotypes distribution had no statistically significance between normotensive group and hypertension group（p ＆gt; 0. 05）and the E3 / 3 genotype had the highest frequeney：76. 6% （82 / 107）,64. 9% （24 / 37）respectively;the allele distribution between the two group was significantly different（ p 〈 0. 05）,the prevalence of ε4 allele in hypertenion group（9. 5% ,7 / 37）was higher than that in normotensive group（2. 3% ,5 / 107）. The differences of systolic blood pressures were significant between hypertension patients with different ApoE phenotypes（p 〈 0. 05）and individuals with the ε4 allele had a significantly higher systolic blood pressure than those carrying other alleles. ConClusion The polymorphism of ApoE gene and systolic blood pressure in longevous elderly in the Xinjiang Uighur people were correlated.
出处
《中国全科医学》
CAS
CSCD
北大核心
2015年第1期47-50,共4页
Chinese General Practice
基金
国家自然科学基金资助项目(31160215)
