摘要
目的探讨Ki-67和p53蛋白在肾癌中的表达和临床意义。方法应用免疫组化方法对66例肾癌组织进行Ki-67和p53蛋白检测。结果在肾癌组织中Ki-67和p53蛋白表达阳性率分别为62.1%和39.4%。Ki-67表达与肾细胞癌分级、分期相关(P<0.05),与肾癌的病理类型无关(P>0.05)。p53表达与肾癌的病理类型、分级、分期无关(P>0.05)。结论 Ki-67表达水平随着肾癌组织的病理分级和临床分期的增高而增高,与肿瘤的生物学行为有一定关系。而p53表达在肾癌生物学行为不具有重要意义。
Objective To study the expression of Ki-67 and p53 in renal cell carcinoma（RCC） and its clinical significance.Methods The protein of Ki-67 and p53 was examined in 66 cases of RCC immunohistochemistry.Results The positive rate of expression of Ki-67 and p53 were 62.1% and 39.4% in RCC.The positive rate of expression of Ki-67 in RCC were significantly related to the clinical stage or clinical grade（P0.05）,but not related to the type of the renal cell carcinoma（P0.05）.The positive rate of expression of p53 in RCC were not related to the clinical stage,the clinical grade and the type of the renal cell carcinoma（P0.05）.Conclusion The expression level of Ki-67 increased markedly with the clinical stage or clinical grade of RCC and it was related to the biological behavior of neoplasms.But p53 plays an unimportant role in RCC.
出处
《临床军医杂志》
CAS
2011年第3期445-446,共2页
Clinical Journal of Medical Officers
