摘要
目的观察FHIT及Ki67蛋白在肾癌组织中的表达情况及其意义。方法采用免疫组化法检测58例肾癌组织中FHIT及Ki67蛋白表达情况。结果FHIT蛋白在正常肾组织中的阳性率明显高于肾癌组织,而Ki67则相反,FHIT与Ki67蛋白表达呈负相关。结论FHIT蛋白表达水平与肾癌的临床分期、病理分级相关,且与Ki67呈负相关。联合检测FHIT、Ki67有助于提高肾癌侵袭转移能力的评估,可作为判定肾癌生物学行为的客观指标。
Objective It is to observe the expression of FHIT protein and Ki67 in renal cell carcinoma （RCC） and to explore its clinical significance. Methods FHIT protein and Ki67 protein expression were determined by immunohistochemical method in 58 cases of RCC. Results The positive rate of expression of FHIT in normal renal tissues was higher than that in RCC, while the positive expression level of Ki67 in normal kidney was lower than that in RCC. FHIT was negatively correlated with Ki67. Conclusion Expression level of FHIT is markedly correlated with clinical classification and pathologic differentiation of RCC and negatively correlated with the expression of Ki67. Combined detection of FHIT and Ki67 may be helpful to evaluate prognosis and infiltrative capability of RCC, and can be used as objective indexes for evaluating biologic behavior of RCC.
出处
《现代中西医结合杂志》
CAS
2010年第4期397-398,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
