摘要
肿瘤新生血管对乳腺癌的生长及转移具有重要作用。血管内皮细胞生长因子受体2(VEGFR2)在肿瘤新生血管内皮细胞中过量表达。超声分子显像(USMI)是通过靶向超声造影剂识别病变血管内皮细胞特异性表达靶点的新技术。大量实验及初步临床研究发现,以VEGFR2为靶向超声造影剂的USMI可用于诊断乳腺癌。本文对VEGFR2靶向超声造影诊断乳腺癌的研究进展进行综述。
Tumor angiogenesis plays an important role in growth and metastasis of breast cancer.Vascular endothelial growth factor receptor 2(VEGFR2)is over-expressed on tumor neo-angiogenesis endothelial cells.Ultrasound molecular imaging(USMI)is a new technology to identify the specific expression of vascular endothelial cells by targeted ultrasound contrast agent(tUCAs).A large number of experimental and preliminary clinical studies have demonstrated that USMI with VEGFR2 tUCAs could be used to diagnose breast cancer.The progresses of VEGFR2 targeted ultrasound contrast imaging in the diagnosis of breast cancer were reviewed in this article.
作者
张欢
阎锋
王红
黄建波
彭玉兰
ZHANG Huan;YAN Feng;WANG Hong;HUANG Jianbo;PENG Yulan(Department of Ultrasound,West China Hospital,Sichuan University,Chengdu 610041,China;Clinical Ultrasound Imaging Drug Research Lab,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《中国医学影像技术》
CSCD
北大核心
2019年第3期463-466,共4页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金面上项目(81571694)
关键词
乳腺肿瘤
超声检查
血管内皮生长因子受体
造影剂
breast neoplasms
ultrasonography
vascular endothelial growth factor receptor
contrast media
