摘要
目的探讨肿瘤相关蛋白Galectin-3和P27与老年早期胃癌患者临床病理的关系,并分析其在微创手术临床预后方面的意义。方法选取58例该院消化内科在2010年7月至2013年10月收治的老年早期胃癌患者作为研究对象,所有患者均行内镜黏膜下剥离术(ESD)。对每例患者术中所取肿瘤及周围正常组织进行Galectin-3和P27的免疫组化检测,并分析其表达量与临床病理的联系,最后分析两种蛋白与ESD术后复发的关系。结果癌组织Galectin-3表达量明显高于正常组织,而P27明显低于正常组织(P<0.05);且分层分析示二者表达量与瘤灶大小和超声黏膜结构有关(P<0.05);进一步分析发现二者是否阳性表达与患者ESD术后复发密切相关(P<0.05),Cox风险比例模型多因素分析进一步显示其影响患者预后(P<0.05)。结论 Galectin-3和P27可能作为早期胃癌临床分子病理的评估指标,且对患者临床预后具有一定的预测意义。
Objective To investigate the relationship between tumor associated Galectin-3 and P27 protein and clinical pathology in elderly patients with early gastric cancer , and analyze their clinical prognostic significance in surgery with minimal invasion .Methods 58 elderly patients with early gastric cancer performed with endoscopic submucosal dissection ( ESD) surgery were selected as the research ob-ject.The immunohistochemical detection of Galectin-3 and P27 in intraoperative tumor tissues and corresponding normal tissues were per-formed on each patient , and to analyze the links between their expression and clinical pathological , and the relationship between the two kinds of protein and recurrence of cancer after ESD .Results The expression of Galectin-3 in tumor tissues was significantly higher than that of normal tissues, insteadly, the expression of P27 was obviously lower than that of normal group (P<0.05);the quantity expression of pro-tein was related to both the tumor size and ultrasonic mucosa structure (P<0.05);the two kinds of protein positive expression were closely related with postoperative recurrence of ESD (P<0.05), and the Cox risk proportion model with multi-factors showed their effects in the prognosis of patients(P<0.05).Conclusions Tumor associated protein Galectin-3 and P27 might be a clinical molecular pathological evalu-ation index for predicting clinical prognosis of early gastric cancer patients .
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2014年第19期5423-5425,共3页
Chinese Journal of Gerontology
基金
重庆市卫生局课题(No.20121-2-431)
泸州市科技局立项课题(〔2009〕72号)
关键词
胃早癌
肿瘤相关蛋白
内镜黏膜下剥离术
Early gastric cancer
Tumor associated protein
Endoscopic submucosal dissection
